期刊
PLANT CELL
卷 30, 期 4, 页码 907-924出版社
OXFORD UNIV PRESS INC
DOI: 10.1105/tpc.18.00052
关键词
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资金
- European Commission Marie Curie Research Training Network (ChIP-ET)
- German Research Foundation [Gr1159/14-1]
- Spanish Ministry of Economy and Competitiveness
- European Regional Development Fund
- Generalitat de Catalunya (AGAUR)
- Global Research Network of the National Research Foundation of Korea
- CERCA Programme/Generalitat de Catalunya
- Spanish Ministry of Economy and Competitiveness through the Severo Ochoa Programme for Centres of Excellence in RD [SEV-2015-0533]
- China Scholarship Council
- Formacion de Personal Investigador fellowship (Ministerio de Economia y Competitividad)
The rhythms of steady-state mRNA expression pervade nearly all circadian systems. However, the mechanisms behind the rhythmic transcriptional synthesis and its correlation with circadian expression remain fully unexplored, particularly in plants. Here, we discovered a multifunctional protein complex that orchestrates the rhythms of transcriptional activity in Arabidopsis thaliana. The expression of the circadian oscillator genes TIMING OF CAB EXPRESSION1/PSEUDO-RESPONSE REGULATOR1 and PSEUDO-RESPONSE REGULATOR5 initially relies on the modular function of the clock-related factor REVEILLE8: its MYB domain provides the DNA binding specificity, while its LCL domain recruits the clock components, NIGHT LIGHT-INDUCIBLE AND CLOCK-REGULATED proteins (LNKs), to target promoters. LNKs, in turn, specifically interact with RNA Polymerase II and the transcript elongation FACT complex to rhythmically co-occupy the target loci. The functional interaction of these components is central for chromatin status, transcript initiation, and elongation as well as for proper rhythms in nascent RNAs. Thus, our findings explain how genome readout of environmental information ultimately results in rhythmic changes of gene expression.
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