期刊
PHYSIOLOGY
卷 33, 期 4, 页码 261-268出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00016.2018
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类别
资金
- Bourse de Recherche de la Fondation Lefoulon Delalande
- Medical Research Council
- INSERM
- Universite de Bordeaux
- MRC [G1002076] Funding Source: UKRI
Pulmonary hypertension is a complex and fatal disease that lacks treatments. Its pathophysiology involves pulmonary artery hyperreactivity, endothelial dysfunction, wall remodelling, inflammation, and thrombosis, which could all depend on ORAI Ca2+ channels. We review the knowledge about ORAI channels in pulmonary artery and discuss the interest to target them in the treatment of pulmonary hypertension.
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