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Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanisms in Vivo
Zhanxiang Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Munc18-1 and Munc18-2 Proteins Modulate β-Cell Ca2+ Sensitivity and Kinetics of Insulin Exocytosis Differently
Slavena A. Mandic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Loss of Granuphilin and Loss of Syntaxin-1A Cause Differential Effects on Insulin Granule Docking and Fusion
Hao Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Dynamics of insulin secretion and the clinical implications for obesity and diabetes
Susumu Seino et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Time-dependent changes in membrane excitability during glucose-induced bursting activity in pancreatic β cells
Chae Young Cha et al.
JOURNAL OF GENERAL PHYSIOLOGY (2011)
Ionic mechanisms and Ca2+ dynamics underlying the glucose response of pancreatic β cells: a simulation study
Chae Young Cha et al.
JOURNAL OF GENERAL PHYSIOLOGY (2011)
Clinical characteristics of recessive and dominant congenital hyperinsulinism due to mutation(s) in the ABCC8/KCNJ11 genes encoding the ATP-sensitive potasium channel in the pancreatic beta cell
Gonul Ocal et al.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2011)
TRPM2: a multifunctional ion channel for calcium signalling
Adriana Sumoza-Toledo et al.
JOURNAL OF PHYSIOLOGY-LONDON (2011)
Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells
Nicole Feldmann et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2011)
GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus
Laura J. McCulloch et al.
MOLECULAR GENETICS AND METABOLISM (2011)
Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans
Rayner Rodriguez-Diaz et al.
NATURE MEDICINE (2011)
Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex
Cong Ma et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone
Yunyun Han et al.
NEURON (2011)
Effects of leptin and adiponectin on pancreatic β-cell function
Yong-ho Lee et al.
METABOLISM-CLINICAL AND EXPERIMENTAL (2011)
ISLET AMYLOID POLYPEPTIDE, ISLET AMYLOID, AND DIABETES MELLITUS
Per Westermark et al.
PHYSIOLOGICAL REVIEWS (2011)
Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays
Thomas Pfeiffer et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2011)
Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR)
Daliang Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic β cells
Colin A. Leech et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2011)
Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans
Patrik Rorsman et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2011)
Synapsin regulation of vesicle organization and functional pools
Maria Bykhovskaia
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2011)
Obesity, insulin resistance and free fatty acids
Guenther Boden
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2011)
Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content
Juris Galvanovskis et al.
INTERFACE FOCUS (2011)
Mapping Dynamic Protein Interactions to Insulin Secretory Granule Behavior with TIRF-FRET
Alice D. Lam et al.
BIOPHYSICAL JOURNAL (2010)
Age- and sex-related prevalence of diabetes mellitus among immigrants to Ontario, Canada
Maria Isabella Creatore et al.
CANADIAN MEDICAL ASSOCIATION JOURNAL (2010)
SNARE Conformational Changes that Prepare Vesicles for Exocytosis
Noriko Takahashi et al.
CELL METABOLISM (2010)
Rim2α Determines Docking and Priming States in Insulin Granule Exocytosis
Takao Yasuda et al.
CELL METABOLISM (2010)
γ-Aminobutyric Acid (GABA) Is an Autocrine Excitatory Transmitter in Human Pancreatic β-Cells
Matthias Braun et al.
DIABETES (2010)
Progression of Diet-Induced Diabetes in C57BL6J Mice Involves Functional Dissociation of Ca2+ Channels From Secretory Vesicles
Stephan C. Collins et al.
DIABETES (2010)
Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets
Reshma Ramracheya et al.
DIABETES (2010)
Unique Arrangement of α- and β-Cells in Human Islets of Langerhans
Domenico Bosco et al.
DIABETES (2010)
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
M. Cnop et al.
DIABETOLOGIA (2010)
A mutation in KCNJ11 causing human hyperinsulinism (Y12X) results in a glucose-intolerant phenotype in the mouse
A. Hugill et al.
DIABETOLOGIA (2010)
Characteristics and Functions of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionate Receptors Expressed in Mouse Pancreatic α-Cells
Jung-Hwa Cho et al.
ENDOCRINOLOGY (2010)
The G(q)/G(11)-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice
Antonia Sassmann et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Activation of the KATP channel by Mg-nucleotide interaction with SUR1
Peter Proks et al.
JOURNAL OF GENERAL PHYSIOLOGY (2010)
BK channels mediate a novel ionic mechanism that regulates glucose-dependent electrical activity and insulin secretion in mouse pancreatic β-cells
Khaled M. Houamed et al.
JOURNAL OF PHYSIOLOGY-LONDON (2010)
Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and complementary roles during secretagogue induced electrical responses
David A. Jacobson et al.
JOURNAL OF PHYSIOLOGY-LONDON (2010)
Leucine metabolism in regulation of insulin secretion from pancreatic beta cells
Jichun Yang et al.
NUTRITION REVIEWS (2010)
Ca2+-Activated K+ Channels: From Protein Complexes to Function
Henrike Berkefeld et al.
PHYSIOLOGICAL REVIEWS (2010)
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hiroshi Hibino et al.
PHYSIOLOGICAL REVIEWS (2010)
Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes
Lorella Marselli et al.
PLOS ONE (2010)
Neuronal Calcium Sensor Synaptotagmin-9 Is Not Involved in the Regulation of Glucose Homeostasis or Insulin Secretion
Natalia Gustavsson et al.
PLOS ONE (2010)
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis et al.
PHARMACOLOGICAL REVIEWS (2010)
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3
Anja Ragvin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic β cell
M. Caroline Jacques-Silva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice
Barbara Colsoul et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes
Anders H. Rosengren et al.
SCIENCE (2010)
Channel-Mediated Tonic GABA Release from Glia
Soojung Lee et al.
SCIENCE (2010)
Doc2b Is a High-Affinity Ca2+ Sensor for Spontaneous Neurotransmitter Release
Alexander J. Groffen et al.
SCIENCE (2010)
The insulin secretory granule as a signaling hub
Jakob Suckalel et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2010)
Exocytotic Properties of Human Pancreatic β-cells
Matthias Braun et al.
MECHANISMS OF EXOCYTOSIS (2009)
Single-Molecule Studies of the Neuronal SNARE Fusion Machinery
Axel T. Brunger et al.
ANNUAL REVIEW OF BIOCHEMISTRY (2009)
PIP2-Binding Site in Kir Channels: Definition by Multiscale Biomolecular Simulations
Phillip J. Stansfeld et al.
BIOCHEMISTRY (2009)
Suppression of Sulfonylurea- and Glucose-Induced Insulin Secretion In Vitro and In Vivo in Mice Lacking the Chloride Transport Protein ClC-3
Dai-Qing Li et al.
CELL METABOLISM (2009)
Chronic Palmitate Exposure Inhibits Insulin Secretion by Dissociation of Ca2+ Channels from Secretory Granules
Michael B. Hoppa et al.
CELL METABOLISM (2009)
Rac1 GTPase: A Rac of All Trades
E. E. Bosco et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2009)
Electrical activity and exocytotic correlates of biphasic insulin secretion from β-cells of canine islets of Langerhans
Stanley Misler et al.
CHANNELS (2009)
Phasic and tonic modes of depolarization-exocytosis coupling in β-cells of porcine islets of Langerhans
Stanley Misler et al.
CHANNELS (2009)
Munc18c Depletion Selectively Impairs the Sustained Phase of Insulin Release
Eunjin Oh et al.
DIABETES (2009)
Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic β-Cells
Martina Duefer et al.
DIABETES (2009)
Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice
W. Fujimoto et al.
DIABETOLOGIA (2009)
Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes
M. J. MacDonald et al.
DIABETOLOGIA (2009)
Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells
M. Braun et al.
DIABETOLOGIA (2009)
The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic β-cell line
Leigh Anne Swayne et al.
EMBO REPORTS (2009)
NALCN: a regulated leak channel
Patrick Gilon et al.
EMBO REPORTS (2009)
Impaired Insulin Exocytosis in Neural Cell Adhesion Molecule-/- Mice Due to Defective Reorganization of the Submembrane F-Actin Network
Charlotta S. Olofsson et al.
ENDOCRINOLOGY (2009)
Deletion of the G Protein-Coupled Receptor 30 Impairs Glucose Tolerance, Reduces Bone Growth, Increases Blood Pressure, and Eliminates Estradiol-Stimulated Insulin Release in Female Mice
Ulrika E. A. Martensson et al.
ENDOCRINOLOGY (2009)
Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol
Jenny Vikman et al.
FASEB JOURNAL (2009)
Regulation of voltage-gated K+ channels by glucose metabolism in pancreatic β-cells
Masashi Yoshida et al.
FEBS LETTERS (2009)
Rab11 and its effector Rip11 participate in regulation of insulin granule exocytosis
Kenji Sugawara et al.
GENES TO CELLS (2009)
The Ca2+ Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate
Anand Radhakrishnan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Characterization of Erg K+ Channels in α- and β-Cells of Mouse and Human Islets
Alexandre B. Hardy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Mechanisms of biphasic insulin-granule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins
Zhanxiang Wang et al.
JOURNAL OF CELL SCIENCE (2009)
Deletion of the von Hippel-Lindau gene in pancreatic β cells impairs glucose homeostasis in mice
James Cantley et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Expression of an activating mutation in the gene encoding the K-ATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes
Christophe A. Girard et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
NAADP mobilizes calcium from acidic organelles through two-pore channels
Peter J. Calcraft et al.
NATURE (2009)
Synaptotagmin IV: a multifunctional regulator of peptidergic nerve terminals
Zhenjie Zhang et al.
NATURE NEUROSCIENCE (2009)
Hyperpolarization-Activated Cation Channels: From Genes to Function
Martin Biel et al.
PHYSIOLOGICAL REVIEWS (2009)
Kiss-and-run exocytosis and fusion pores of secretory vesicles in human β-cells
Salma T. Hanna et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2009)
Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
K. Lemaire et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
miR-375 maintains normal pancreatic α- and β-cell mass
Matthew N. Poy et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The cAMP Sensor Epac2 Is a Direct Target of Antidiabetic Sulfonylurea Drugs
Chang-Liang Zhang et al.
SCIENCE (2009)
Membrane Fusion: Grappling with SNARE and SM Proteins
Thomas C. Sudhof et al.
SCIENCE (2009)
Metabolic cycling in control of glucose-stimulated insulin secretion
Mette V. Jensen et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)
Insulin signaling in the pancreatic beta-cell
Ingo B. Leibiger et al.
ANNUAL REVIEW OF NUTRITION (2008)
Regulation of the expression of components of the exocytotic machinery of insulin-secreting cells by microRNAs
Pascal Lovis et al.
BIOLOGICAL CHEMISTRY (2008)
Glutamate is a positive autocrine signal for glucagon release
Over Cabrera et al.
CELL METABOLISM (2008)
CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells
Dina Speidel et al.
CELL METABOLISM (2008)
Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
Oleg Dyachok et al.
CELL METABOLISM (2008)
Voltage-gated ion channels in human pancreatic β-cells:: Electrophysiological characterization and role in insulin secretion
Matthias Braun et al.
DIABETES (2008)
Pancreatic β-cell mass in European subjects with type 2 diabetes
J. Rahier et al.
DIABETES OBESITY & METABOLISM (2008)
Adipose tissue fatty acid metabolism in insulin-resistant men
A. S. T. Bickerton et al.
DIABETOLOGIA (2008)
Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic β-cells
Fuzhen Xia et al.
ENDOCRINOLOGY (2008)
Obesity and Free Fatty Acids
Guenther Boden
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA (2008)
pVHL is a regulator of glucose metabolism and insulin secretion in pancreatic β cells
Jens Zehetner et al.
GENES & DEVELOPMENT (2008)
Filamentous actin regulates insulin exocytosis through direct interaction with syntaxin 4
Jenna L. Jewell et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Regulation of Insulin Granule Turnover in Pancreatic β-Cells by Cleaved ICA512
Mirko Trajkovski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
How ATP inhibits the open KATP channel
Tim J. Craig et al.
JOURNAL OF GENERAL PHYSIOLOGY (2008)
Role of the Vesicular Chloride Transporter ClC-3 in Neuroendocrine Tissue
Tanja Maritzen et al.
JOURNAL OF NEUROSCIENCE (2008)
Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic β-cells
Matthew J. Merrins et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
Novel aspects of the molecular mechanisms controlling insulin secretion
Lena Eliasson et al.
JOURNAL OF PHYSIOLOGY-LONDON (2008)
The Orphan Transporter Rxt1/NTT4 (SLC6A17) Functions as a Synaptic Vesicle Amino Acid Transporter Selective for Proline, Glycine, Leucine, and Alanine
Leonardo A. Parra et al.
MOLECULAR PHARMACOLOGY (2008)
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
Kazuki Yasuda et al.
NATURE GENETICS (2008)
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
Hiroyuki Unoki et al.
NATURE GENETICS (2008)
The fusion pores of Ca2+-triggered exocytosis
Meyer B. Jackson et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)
Electrophysiological and immunocytochemical evidence for P2X purinergic receptors in pancreatic β cells
Amelia M. Silva et al.
PANCREAS (2008)
Adrenaline-induced hyperpolarization of mouse pancreatic islet cells is mediated by G protein-gated inwardly rectifying potassium (GIRK) channels
Shachar Iwanir et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2008)
Cell coupling in mouse pancreatic β-cells measured in intact islets of Langerhans
Quan Zhang et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2008)
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
Natalia Gustavsson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Identification of a vesicular nucleotide transporter
Keisuke Sawada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Docking is not a prerequisite but a temporal constraint for fusion of secretory granules
Kazuo Kasai et al.
TRAFFIC (2008)
Type 2 diabetes: new genes, new understanding
Inga Prokopenko et al.
TRENDS IN GENETICS (2008)
Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance
Kirsten Vollmer et al.
DIABETES (2008)
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by CAMP
Tadao Shibasaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
SNAREing voltage-gated K+ and ATP-Sensitive K+ channels:: Tuning β-Cell excitability with syntaxin-1A and other exocytotic proteins
Yuk M. Leung et al.
ENDOCRINE REVIEWS (2007)
ATP-sensitive K+ channels and disease:: from molecule to malady
Frances M. Ashcroft
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2007)
The physiology of glucagon-like peptide 1
Jens Juul Holst
PHYSIOLOGICAL REVIEWS (2007)
Kv2.1 Ablation alters glucose-induced islet electrical activity, enhancing insulin secretion
David A. Jacobson et al.
CELL METABOLISM (2007)
Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreas
Y. Guiot et al.
DIABETOLOGIA (2007)
The actions of a novel potent islet β-cell-specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1
Betty Ng et al.
DIABETES (2007)
MicroRNA-124a regulates Foxa2 expression and intracellular signaling in pancreatic β-cell lines
Nadine Baroukh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane
Charlotta S. Olofsson et al.
DIABETES (2007)
The calcium-sensing protein synaptotagmin 7 is expressed on different endosomal compartments in endocrine, neuroendocrine cells or neurons but not on large dense core vesicles
Carole Monterrat et al.
HISTOCHEMISTRY AND CELL BIOLOGY (2007)
A KATP channel-dependent pathway within α cells regulates glucagon release from both rodent and human islets of langerhans
Patrick E. MacDonald et al.
PLOS BIOLOGY (2007)
Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator
Daniel Johnson et al.
DIABETES (2007)
Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice
J. Cantley et al.
DIABETOLOGIA (2007)
Synaptotagmin-1,-2, and-9:: Ca2+ sensors for fast release that specify distinct presynaptic properties in subsets of neurons
Jun Xu et al.
NEURON (2007)
Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis
Mica Ohara-Imaizumi et al.
JOURNAL OF CELL BIOLOGY (2007)
Human insulin vesicle dynamics during pulsatile secretion
Darren J. Michael et al.
DIABETES (2007)
R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion
Quan Zhang et al.
NATURE CELL BIOLOGY (2007)
Glucotoxicity inhibits late steps of insulin exocytosis
Mathilde Dubois et al.
ENDOCRINOLOGY (2007)
Cx36-mediated coupling reduces β-cell heterogeneity, confines the stimulating glucose concentration range, and affects insulin release kinetics
Stephan Speier et al.
DIABETES (2007)
Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion
Zhanxiang Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic β cells
Matthias Braun et al.
JOURNAL OF GENERAL PHYSIOLOGY (2007)
Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic β-cells
Wasim El-Kholy et al.
MOLECULAR ENDOCRINOLOGY (2007)
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek et al.
NATURE (2007)
A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse
Alexander F. Jeans et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Gating modifier peptides as probes of pancreatic β-cell physiology
James Herrington
TOXICON (2007)
Nanodomains of single Ca2+ channels contribute to action potential repolarization in cortical neurons
Andreas Mueller et al.
JOURNAL OF NEUROSCIENCE (2007)
Tomographic molecular imaging and 3D quantification within adult mouse organs
Tomas Alanentalo et al.
NATURE METHODS (2007)
The importance of free fatty acids in the development of Type 2 diabetes
J. P. H. Wilding
DIABETIC MEDICINE (2007)
Subunit-specific modulation of T-type calcium channels by zinc
Achraf Traboulsie et al.
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia - Possible contribution to impaired incretin effects in diabetes
Gang Xu et al.
DIABETES (2007)
Defining a binding pocket for sulfonylureas in ATP-sensitive potassium channels
Wanda H. Vila-Carriles et al.
FASEB JOURNAL (2007)
An SCN9A channelopathy causes congenital inability to experience pain
James J. Cox et al.
NATURE (2006)
Mechanisms linking obesity to insulin resistance and type 2 diabetes
Steven E. Kahn et al.
NATURE (2006)
Nutrient control of insulin secretion in isolated normal human islets
Jean-Claude Henquin et al.
DIABETES (2006)
Scavenging of 14-3-3 proteins reveals their involvement in the cell-surface transport of ATP-sensitive K+ channels
Katja Heusser et al.
JOURNAL OF CELL SCIENCE (2006)
In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion
Fabrice Chimienti et al.
JOURNAL OF CELL SCIENCE (2006)
Hyperinsulinism in mice with heterozygous loss of KATP channels
M. S. Remedi et al.
DIABETOLOGIA (2006)
Release of small transmitters through kiss-and-run fusion pores in rat pancreatic β cells
Patrick E. MacDonald et al.
CELL METABOLISM (2006)
Oscillatory membrane potential response to glucose in islet β-cells:: A comparison of islet-cell electrical activity in mouse and rat
Jocelyn E. Manning Fox et al.
ENDOCRINOLOGY (2006)
MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells
Valerie Plaisance et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
ATP sensitivity of the ATP-Sensitive K+ channel in intact and permeabilized pancreatic β-cells
Andrei I. Tarasov et al.
DIABETES (2006)
Glucose induces opposite intracellular ca2+ concentration oscillatory patterns in identified α- and β-cells within intact human islets of langerhans
Ivan Quesada et al.
DIABETES (2006)
Glucose acutely decreases pH of secretory granules in mouse pancreatic islets - Mechanisms and influence on insulin secretion
Patrick Stiernet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Activating mutations in the ABCC8 gene in neonatal diabetes mellitus
Andrey P. Babenko et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations
Ewan R. Pearson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Control of single channel conductance in the outer vestibule of the Kv2.1 potassium channel
Josef G. Trapani et al.
JOURNAL OF GENERAL PHYSIOLOGY (2006)
Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice
Toyonori Kato et al.
CELL METABOLISM (2006)
Tomosyn-1 is involved in a post-docking event required for pancreatic β-cell exocytosis
Severine Cheviet et al.
JOURNAL OF CELL SCIENCE (2006)
Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion
Ferenc Deak et al.
EMBO JOURNAL (2006)
cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic β cells and rat INS-1 cells
Guoxin Kang et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
Munc13-1 is required for the sustained release of insulin from pancreatic β cells
Lijun Kang et al.
CELL METABOLISM (2006)
Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells
Sheila Vignali et al.
JOURNAL OF PHYSIOLOGY-LONDON (2006)
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5
H Mziaut et al.
NATURE CELL BIOLOGY (2006)
Effect of donor age on function of isolated human islets
SH Ihm et al.
DIABETES (2006)
DOC2A and DOC2B are sensors for neuronal activity with unique calcium-dependent and kinetic properties
AJA Groffen et al.
JOURNAL OF NEUROCHEMISTRY (2006)
The Zn2+-transporting pathways in pancreatic β-cells -: A role for the L-type voltage-gated Ca2+ channel
AV Gyulkhandanyan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Sustained exposure to high glucose concentrations modifies glucose signaling and the mechanics of secretory vesicle fusion in primary rat pancreatic β-cells
T Tsuboi et al.
DIABETES (2006)
KATP channels as molecular sensors of cellular metabolism
CG Nichols
NATURE (2006)
Tomosyn is expressed in β-cells and negatively regulates insulin exocytosis
W Zhang et al.
DIABETES (2006)
Pancreatic β-cells secrete insulin in fast- and slow-release forms
DJ Michael et al.
DIABETES (2006)
The unique cytoarchitecture of human pancreatic islets has implications for islet cell function
O Cabrera et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Critical role of gap junction coupled KATP channel activity for regulated insulin secretion
JV Rocheleau et al.
PLOS BIOLOGY (2006)
Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients
CG Ostenson et al.
DIABETES (2006)
In vivo and in vitro glucose-induced biphasic insulin secretion in the mouse -: Pattern and role of cytoplasmic Ca2+ and amplification signals in β-cells
JC Henquin et al.
DIABETES (2006)
Reduction in voltage-gated K+ currents in primary cultured rat pancreatic β-cells by linoleic acids
DD Feng et al.
ENDOCRINOLOGY (2006)
Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells
BA Spurlin et al.
MOLECULAR ENDOCRINOLOGY (2006)
Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells
PE MacDonald et al.
JOURNAL OF CELL SCIENCE (2005)
3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1
MV Mikhailov et al.
EMBO JOURNAL (2005)
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels
GA Gutman et al.
PHARMACOLOGICAL REVIEWS (2005)
Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes
F Fehse et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2005)
Granuphilin molecularly docks insulin granules to the fusion machinery
H Gomi et al.
JOURNAL OF CELL BIOLOGY (2005)
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
SYL Zhang et al.
NATURE (2005)
Pharmacological properties and functional role of Kslow current in mouse pancreatic β-cells:: SK channels contribute to Kslow tail current and modulate insulin secretion
M Zhang et al.
JOURNAL OF GENERAL PHYSIOLOGY (2005)
PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis
S Seino et al.
PHYSIOLOGICAL REVIEWS (2005)
Acute effects of insulin on beta-cells from transplantable human islets
DS Luciani et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2005)
Adenovirus-mediated silencing of Synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets
M Iezzi et al.
FEBS LETTERS (2005)
Selective nucleotide-release from dense-core granules in insulin-secreting cells
S Obermüller et al.
JOURNAL OF CELL SCIENCE (2005)
Activating mutations in Kir6.2 and neonatal diabetes - New clinical syndromes, new scientific insights, and new therapy
AT Hattersley et al.
DIABETES (2005)
C'rlucagon-like peptide 1 regulates sequential and compound exocytosis in pancreatic islet β-cells
EP Kwan et al.
DIABETES (2005)
A Munc13/RIM/Rab3 tripartite complex:: from priming to plasticity?
I Dulubova et al.
EMBO JOURNAL (2005)
Redox control of exocytosis -: Regulatory role of NADPH, thioredoxin, and glutaredoxin
R Ivarsson et al.
DIABETES (2005)
Loss of connexin36 channels alters β-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release
MA Ravier et al.
DIABETES (2005)
Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young
AL Gloyn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Functional and molecular defects of pancreatic islets in human type 2 diabetes
S Del Guerra et al.
DIABETES (2005)
Genetic background determines the size and structure of the endocrine pancreas
T Bock et al.
DIABETES (2005)
Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes
MJ Riedel et al.
HUMAN GENETICS (2005)
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation
K Kasai et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients
M Anello et al.
DIABETOLOGIA (2005)
KATP-channels in beta-cells in tissue slices are directly modulated by millimolar ATP
S Speier et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2005)
Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit
JF Antcliff et al.
EMBO JOURNAL (2005)
Molecular mechanisms of mitochondrial diabetes (MIDD)
JA Maassen et al.
ANNALS OF MEDICINE (2005)
Ca(v)2.3 calcium channels control second-phase insulin release
XJ Jing et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Capacitance measurements of exocytosis in mouse pancreatic α-, β- and δ-cells within intact islets of Langerhans
S Göpel et al.
JOURNAL OF PHYSIOLOGY-LONDON (2004)
Complexin I regulates glucose-induced secretion in pancreatic β-cells
A Abderrahmani et al.
JOURNAL OF CELL SCIENCE (2004)
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes
AL Gloyn et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic β-cells
M Braun et al.
JOURNAL OF GENERAL PHYSIOLOGY (2004)
Oscillations of membrane potential and cytosolic Ca2+ concentration in SUR1-/- beta cells
M Düfer et al.
DIABETOLOGIA (2004)
Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis
T Shibasaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Syntaxin-1A binds the nucleotide-binding folds of sulphonylurea receptor 1 to regulate the KATP channel
EA Pasyk et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
B Mackenzie et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects
Y Kanai et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
The SK3 subunit of small conductance Ca2+-activated K+ channels interacts with both SK1 and SK2 subunits in a heterologous expression system
AS Monaghan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
GABAB receptor activation inhibits exocytosis in rat pancreatic β-cells by G-protein-dependent activation of calcineurin
M Braun et al.
JOURNAL OF PHYSIOLOGY-LONDON (2004)
Large dense-core vesicle exocytosis in pancreatic β-cells monitored by capacitance measurements
T Kanno et al.
METHODS (2004)
Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in β-cells
M Trajkovski et al.
JOURNAL OF CELL BIOLOGY (2004)
A highly Ca2+-sensitive pool of granules is regulated by glucose and protein kinases in insulin-secreting INS-1 cells
Y Yang et al.
JOURNAL OF GENERAL PHYSIOLOGY (2004)
Five stages of evolving β-cell dysfunction during progression to diabetes
GC Weir et al.
DIABETES (2004)
Apolipoprotein CIII promotes Ca2+-dependent β cell death in type 1 diabetes
L Juntti-Berggren et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis
T Shibasaki et al.
DIABETES (2004)
Fluorescent cargo proteins in pancreatic β-cells:: Design determines secretion kinetics at exocytosis
DJ Michael et al.
BIOPHYSICAL JOURNAL (2004)
Synaptotagmin V and IX isoforms control Ca2+-dependent insulin exocytosis
M Iezzi et al.
JOURNAL OF CELL SCIENCE (2004)
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in beta IRKO mice
K Otani et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)
A pancreatic islet-specific microRNA regulates insulin secretion
MN Poy et al.
NATURE (2004)
Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic β-cells
CS Olofsson et al.
JOURNAL OF PHYSIOLOGY-LONDON (2004)
Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells
M Matsumoto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Adipose tissue as an endocrine organ
EE Kershaw et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2004)
Functional coupling of intracellular calcium and inactivation of voltage-gated Kv1.1/Kvβ1.1 A-type K+ channels
F Jow et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Removal of Ca2+ channel β3 Subunit enhances Ca2+ oscillation frequency and insulin exocytosis
PO Berggren et al.
CELL (2004)
Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission
C Bark et al.
JOURNAL OF NEUROSCIENCE (2004)
Molecular structure and function of the glycine receptor chloride channel
JW Lynch
PHYSIOLOGICAL REVIEWS (2004)
Palmitate-induced Ca2+-signaling in pancreatic beta-cells
O Remizov et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2003)
Kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 β-cells
A Varadi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis
L Waselle et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
S Kashyap et al.
DIABETES (2003)
Syntaxin 4 and Synip (syntaxin 4 interacting protein) regulate insulin secretion in the pancreatic β HC-9 cell
T Saito et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Direct interaction of target SNAREs with the Kv2.1 channel - Modal regulation of channel activation and inactivation gating
I Michaelevski et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Hierarchy of the β-cell signals controlling insulin secretion
JC Henquin et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2003)
Small-conductance calcium-activated K+ channels are expressed in pancreatic islets and regulate glucose responses
NA Tamarina et al.
DIABETES (2003)
A novel approach to in situ characterization of pancreatic β-cells
S Speier et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2003)
Impaired insulin secretion and glucose tolerance in β cell-selective CaV1.2 Ca2+ channel null mice
V Schulla et al.
EMBO JOURNAL (2003)
Insulin granule dynamics in pancreatic beta cells
P Rorsman et al.
DIABETOLOGIA (2003)
Differential control of the releasable vesicle pools by SNAP-25 splice variants and SNAP-23
JB Sorensen et al.
CELL (2003)
Sulphonylurea action revisited - the post-cloning era
FM Gribble et al.
DIABETOLOGIA (2003)
Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking
YM Leung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
On-line analysis of gap junctions reveals more efficient electrical than dye coupling between islet cells
I Quesada et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells
HL Olsen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Insulin secretory deficiency and glucose intolerance in Rab3A null mice
K Yaekura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Y Itoh et al.
NATURE (2003)
The insulin secretory granule is the major site of KATP channels of the endocrine pancreas
XH Geng et al.
DIABETES (2003)
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells
L Eliasson et al.
JOURNAL OF GENERAL PHYSIOLOGY (2003)
A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs
K Kotarsky et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
NAADP:: A new second messenger for glucose-induced Ca2+ responses in clonal pancreatic β cells
R Masgrau et al.
CURRENT BIOLOGY (2003)
Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population
F Reimann et al.
DIABETOLOGIA (2003)
Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
AL Gloyn et al.
DIABETES (2003)
Critical reduction in β-cell mass results in two distinct outcomes over time -: Adaptation with impaired glucose tolerance or decompensated diabetes
DR Laybutt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Amplification of exocytosis by Ca (2+)-induced Ca2+ release in INS-1 pancreatic beta cells
GX Kang et al.
JOURNAL OF PHYSIOLOGY-LONDON (2003)
Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release
T Otonkoski et al.
DIABETES (2003)
Molecular physiology of low-voltage-activated T-type calcium channels
E Perez-Reyes
PHYSIOLOGICAL REVIEWS (2003)
Piccolo, a Ca2+ sensor in pancreatic β-cells -: Involvement of cAMP-GEFII•Rim2•Piccolo complex in cAMP-dependent exocytosis
K Fujimoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Methyl pyruvate stimulates pancreatic β-cells by a direct effect on KATP channels, and not as a mitochondrial substrate
M Düfer et al.
BIOCHEMICAL JOURNAL (2002)
Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes
C Schwanstecher et al.
DIABETES (2002)
The common single nucleotide polymorphism E23K in KIR6.2 sensitizes pancreatic β-cell ATP-sensitive potassium channels toward activation through nucleoside diphosphates
C Schwanstecher et al.
DIABETES (2002)
cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets
M Nakazaki et al.
DIABETES (2002)
Regulation of pancreatic β-cell glucokinase -: From basics to therapeutics
FM Matschinsky
DIABETES (2002)
Glucagon-like peptide-1 receptor activation antagonizes voltage-dependent repolarizing K+ currents in β-cells -: A possible glucose-dependent insulinotropic mechanism
PE MacDonald et al.
DIABETES (2002)
Glucose-dependent regulation of rhythmic action potential firing in pancreatic β-cells by KATP-channel modulation
T Kanno et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)
Involvement of conventional kinesin in glucose-stimulated secretory granule movements and exocytosis in clonal pancreatic β-cells
A Varadi et al.
JOURNAL OF CELL SCIENCE (2002)
Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-Dependent K+ channels in neuroendocrine islet β-cells through an interaction with the channel N terminus
PE MacDonald et al.
MOLECULAR ENDOCRINOLOGY (2002)
G protein-independent activation of an inward Na+ current by muscarinic receptors in mouse pancreatic β-cells
JF Rolland et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose
C Shiota et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia
O Tschritter et al.
DIABETES (2002)
Calcium-activated K+ channels of mouse β-cells are controlled by both store and cytoplasmic Ca2+:: Experimental and theoretical studies
PB Goforth et al.
JOURNAL OF GENERAL PHYSIOLOGY (2002)
Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet
N Takahashi et al.
SCIENCE (2002)
Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a
S Torii et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas
N Wierup et al.
REGULATORY PEPTIDES (2002)
Pancreatic β-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis
T Coppola et al.
MOLECULAR BIOLOGY OF THE CELL (2002)
Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells
CS Olofsson et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2002)
The SNAREs vti1a and vti1b have distinct localization and SNARE complex partners
V Kreykenbohm et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2002)
Metabotropic glutamate and GABAB receptors contribute to the modulation of glucose-stimulated insulin secretion in pancreatic beta cells
NL Brice et al.
DIABETOLOGIA (2002)
Synaptotagmins form a hierarchy of exocytotic Ca2+ sensors with distinct Ca2+ affinities
S Sugita et al.
EMBO JOURNAL (2002)
Section 2: Biphasic insulin release: Pools and signal modulation - Modeling phasic insulin release - Immediate and time-dependent effects of glucose
R Nesher et al.
DIABETES (2002)
A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse β-cells
S Barg et al.
DIABETES (2002)
Signals and pools underlying biphasic insulin secretion
JC Henquin et al.
DIABETES (2002)
Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells
S Barg et al.
NEURON (2002)
RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone
S Schoch et al.
NATURE (2002)
The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules
Z Yi et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Mitochondrial function in normal and diabetic β-cells
P Maechler et al.
NATURE (2001)
Critical role of cAMP-GEFII.Rim2 complex in incretin-potentiated insulin secretion
Y Kashima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Fast exocytosis with few Ca2+ channels in insulin-secreting mouse pancreatic B cells
S Barg et al.
BIOPHYSICAL JOURNAL (2001)
SNARE function analyzed in synaptobrevin/VAMP knockout mice
S Schoch et al.
SCIENCE (2001)
SNARE-complex disassembly by NSF follows synaptic-vesicle fusion
JT Littleton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Insulin activates ATP-sensitive K+ channels in pancreatic β-cells through a phosphatidylinositol 3-kinase-dependent pathway
FA Khan et al.
DIABETES (2001)
Somatostatin inhibits exocytosis in rat pancreatic α-cells by Gi2-dependent activation of calcineurin and depriming of secretory granules
J Gromada et al.
JOURNAL OF PHYSIOLOGY-LONDON (2001)
Glycogen accumulation in rat pancreatic islets - In vitro experiments
M Doherty et al.
ENDOCRINE (2001)
VAMP3 null mice display normal constitutive, insulin- and exercise-regulated vesicle trafficking
CM Yang et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells
B Leibiger et al.
MOLECULAR CELL (2001)
Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials
G Larsson-Nyrén et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2001)
ATP interaction with the open state of the KATP channel
D Enkvetchakul et al.
BIOPHYSICAL JOURNAL (2001)
P2 receptor agonists stimulate insulin release from human pancreatic islets
J Fernandez-Alvarez et al.
PANCREAS (2001)
Amplitude modulation of pulsatile insulin secretion by intrapancreatic ganglion neurons
L Sha et al.
DIABETES (2001)
Glucose- and arginine-induced insulin secretion by human pancreatic β-cells:: the role of HERG K+ channels in firing and release
B Rosati et al.
FASEB JOURNAL (2000)
Differential patterns of glucose-induced electrical activity and intracellular calcium responses in single mouse and rat pancreatic islets
CM Antunes et al.
DIABETES (2000)
Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes
JP Silva et al.
NATURE GENETICS (2000)
cAMP-GEFII is a direct target of cAMP in regulated exocytosis
N Ozaki et al.
NATURE CELL BIOLOGY (2000)
Triggering and amplifying pathways of regulation of insulin secretion by glucose
JC Henquin
DIABETES (2000)
Patch-clamp characterisation of somatostatin-secreting δ-cells in intact mouse pancreatic islets
SO Göpel et al.
JOURNAL OF PHYSIOLOGY-LONDON (2000)
Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor α and estrogen receptor β
A Nadal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Novel method for measurement of submembrane ATP concentration
FM Gribble et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes
M Hollingdal et al.
DIABETES (2000)
Autonomic regulation of islet hormone secretion -: Implications for health and disease
B Ahrén
DIABETOLOGIA (2000)
Sur1 knockout mice -: A model for KATP channel-independent regulation of insulin secretion
V Seghers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Cloning of a T-type Ca2+ channel isoform in insulin-secreting cells
H Zhuang et al.
DIABETES (2000)
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