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Notable epigenetic role of hyperhomocysteinemia in atherogenesis
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LIPIDS IN HEALTH AND DISEASE (2014)
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Enzyme clustering accelerates processing of intermediates through metabolic channeling
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In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
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We Have Contact: Endothelial Cell-Smooth Muscle Cell Interactions
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Sulforaphane Attenuation of Type 2 Diabetes-Induced Aortic Damage Was Associated with the Upregulation of Nrf2 Expression and Function
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OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
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Endothelial NADPH oxidases: which NOX to target in vascular disease?
Grant R. Drummond et al.
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Mohamed Ouzzine et al.
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Role of Endothelial Nitric Oxide Synthase in Diabetic Nephropathy: Lessons from Diabetic eNOS Knockout Mice
Takamune Takahashi et al.
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Mitochondria, endothelial cell function, and vascular diseases
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FRONTIERS IN PHYSIOLOGY (2014)
Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-β1 and prooxidant enzyme NADPH oxidase
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REDOX BIOLOGY (2014)
Methods for integration of transcriptomic data in genome-scale metabolic models
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COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2014)
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CANCER & METABOLISM (2014)
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)
Histone and DNA Methylation-Mediated Epigenetic Downregulation of Endothelial Kruppel-Like Factor 2 by Low-Density Lipoprotein Cholesterol
Ajay Kumar et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)
Endothelium-specific insulin resistance leads to accelerated atherosclerosis in areas with disturbed flow patterns: A role for reactive oxygen species
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ATHEROSCLEROSIS (2013)
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Fumihiko Takizawa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
Uncoupling of eNOS contributes to redox-sensitive leukocyte recruitment and microvascular leakage elicited by methylglyoxal
Yang Su et al.
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Crucial roles of Nox2-derived oxidative stress in deteriorating the function of insulin receptors and endothelium in dietary obesity of middle-aged mice
Junjie Du et al.
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Immune-suppressive properties of the tumor microenvironment
Juergen C. Becker et al.
CANCER IMMUNOLOGY IMMUNOTHERAPY (2013)
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Yang Su et al.
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Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis
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Katrien De Bock et al.
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Christian Rask-Madsen et al.
CELL METABOLISM (2013)
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Kathrina L. Marcelo et al.
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Induction of Vascular Insulin Resistance and Endothelin-1 Expression and Acceleration of Atherosclerosis by the Overexpression of Protein Kinase C- Isoform in the Endothelium
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CIRCULATION RESEARCH (2013)
Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study
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Mark T. Kearney
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EMBO JOURNAL (2013)
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EMBO MOLECULAR MEDICINE (2013)
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EPILEPSIA (2013)
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Joshua A. Beckman et al.
EUROPEAN HEART JOURNAL (2013)
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Francesco Paneni et al.
EUROPEAN HEART JOURNAL (2013)
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Barbara Glowinska-Olszewska et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2013)
Wnt signaling in the vasculature
Marco Reis et al.
EXPERIMENTAL CELL RESEARCH (2013)
Crosstalk between oxygen- and nitric oxide-dependent signaling pathways in angiogenesis
Peter Fraisl
EXPERIMENTAL CELL RESEARCH (2013)
Angiopoietin signaling in the vasculature
Lauri Eklund et al.
EXPERIMENTAL CELL RESEARCH (2013)
Bosentan inhibits oxidative and nitrosative stress and rescues occlusive pulmonary hypertension
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FREE RADICAL BIOLOGY AND MEDICINE (2013)
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INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2013)
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Kyoko Hida et al.
JOURNAL OF BIOCHEMISTRY (2013)
Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis
Guo-Xiang Ruan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Intratumoral, not circulating, endothelial progenitor cells share genetic aberrations with glial tumor cells
Ping-Pin Zheng et al.
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Matthew G. Vander Heiden
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Acrolein stimulates the synthesis of IL-6 and C-reactive protein (CRP) in thrombosis model mice and cultured cells
Ryotaro Saiki et al.
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Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein
Emilie Cossette et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2013)
Control of angiogenesis by AIBP-mediated cholesterol efflux
Longhou Fang et al.
NATURE (2013)
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Abdou Rachid Thiam et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B
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Reactive Oxygen Species Modulate the Barrier Function of the Human Glomerular Endothelial Glycocalyx
Anurag Singh et al.
PLOS ONE (2013)
Insulin-Mediated Activation of the L-Arginine Nitric Oxide Pathway in Man, and Its Impairment in Diabetes
Niwanthi W. Rajapakse et al.
PLOS ONE (2013)
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PLOS ONE (2013)
Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency
Boris Betz et al.
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Cross-talk between SIRT1 and p66Shc in vascular diseases
Hou-Zao Chen et al.
TRENDS IN CARDIOVASCULAR MEDICINE (2013)
Metabolism in physiological cell proliferation and differentiation
Michalis Agathocleous et al.
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Control of vessel sprouting by genetic and metabolic determinants
Guy Eelen et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)
Isolation and genome-wide expression and methylation characterization of CD31+ cells from normal and malignant human prostate tissue
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ONCOTARGET (2013)
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Methylglyoxal, obesity, and diabetes
Paulo Matafome et al.
ENDOCRINE (2013)
Tumor Endothelial Cells Acquire Drug Resistance by MDR1 Up-Regulation via VEGF Signaling in Tumor Microenvironment
Kosuke Akiyama et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
Heterogeneity of Tumor Endothelial Cells Comparison between Tumor Endothelial Cells Isolated from High- and Low-Metastatic Tumors
Noritaka Ohga et al.
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Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway
Harun Elmasri et al.
ANGIOGENESIS (2012)
Insulin transcriptionally regulates argininosuccinate synthase to maintain vascular endothelial function
Ricci J. Haines et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation
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Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells
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Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells
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FoxOs Integrate Pleiotropic Actions of Insulin in Vascular Endothelium to Protect Mice from Atherosclerosis
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CHEMMEDCHEM (2012)
Endothelium-Selective Activation of AMP-Activated Protein Kinase Prevents Diabetes Mellitus-Induced Impairment in Vascular Function and Reendothelialization via Induction of Heme Oxygenase-1 in Mice
Francois Y. L. Li et al.
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Yutaka Hasegawa et al.
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Colin Cunnington et al.
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Distinguishing Hyperglycemic Changes by Set7 in Vascular Endothelial Cells
Jun Okabe et al.
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Gene Silencing of the Mitochondrial Adaptor p66Shc Suppresses Vascular Hyperglycemic Memory in Diabetes
Francesco Paneni et al.
CIRCULATION RESEARCH (2012)
The Role of Nitric Oxide on Endothelial Function
Dimitris Tousoulis et al.
CURRENT VASCULAR PHARMACOLOGY (2012)
Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin
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Metanx Alleviates Multiple Manifestations of Peripheral Neuropathy and Increases Intraepidermal Nerve Fiber Density in Zucker Diabetic Fatty Eats
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A. Rajwani et al.
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Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?
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Ulrich Foerstermann et al.
EUROPEAN HEART JOURNAL (2012)
The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate
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FREE RADICAL BIOLOGY AND MEDICINE (2012)
The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II
Isabel Diebold et al.
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Prevention of VEGF-induced growth and tube formation in human retinal endothelial cells by aldose reductase inhibition
Umesh C. S. Yadav et al.
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A Single Fusion Signal for t(14;18)(q32;q21) Translocation Is Present in Both the Follicular Lymphoma and Local Endothelial Cells
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Using the reconstructed genome-scale human metabolic network to study physiology and pathology
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A novel mechanism of coenzyme Q10 protects against human endothelial cells from oxidative stress-induced injury by modulating NO-related pathways
Kun-Ling Tsai et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2012)
C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction
Stephen Kaptoge et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis
Pierre Sonveaux et al.
PLOS ONE (2012)
Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells
Christophe J. De Saedeleer et al.
PLOS ONE (2012)
The influence of high glucose on the aerobic metabolism of endothelial EA.hy926 cells
Agnieszka Koziel et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2012)
Endothelial mitochondria-less respiration, more integration
Lukas N. Groschner et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2012)
Methylglyoxal promotes oxidative stress and endothelial dysfunction
Cristina M. Sena et al.
PHARMACOLOGICAL RESEARCH (2012)
Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation
Ciro Coletta et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Nitric oxide synthase uncoupling: A therapeutic target in cardiovascular diseases
Nathan D. Roe et al.
VASCULAR PHARMACOLOGY (2012)
Tumor Endothelial Cells
Andrew C. Dudley
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Pulmonary Artery Endothelium Resident Endothelial Colony-Forming Cells in Pulmonary Arterial Hypertension
Heng T. Duong et al.
Pulmonary Circulation (2012)
Mast Cell Number, Phenotype, and Function in Human Pulmonary Arterial Hypertension
Samar Farha et al.
Pulmonary Circulation (2012)
Metabolomic Analysis of Bone Morphogenetic Protein Receptor Type 2 Mutations in Human Pulmonary Endothelium Reveals Widespread Metabolic Reprogramming
Joshua P. Fessel et al.
Pulmonary Circulation (2012)
Diabetic angiopathy and angiogenic defects
Ling Xu et al.
FIBROGENESIS & TISSUE REPAIR (2012)
AMP-activated protein kinase rescues the angiogenic functions of endothelial progenitor cells via manganese superoxide dismutase induction in type 1 diabetes
Xiao-Rong Wang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2011)
Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo
Ravinder Tammali et al.
ANGIOGENESIS (2011)
Human Aldose Reductase Expression Accelerates Atherosclerosis in Diabetic Apolipoprotein E-/- Mice
Srinivasan Vedantham et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)
Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression
Marcela Franco et al.
BLOOD (2011)
The role of shear stress in Blood-Brain Barrier endothelial physiology
Luca Cucullo et al.
BMC NEUROSCIENCE (2011)
HuR keeps an angiogenic switch on by stabilising mRNA of VEGF and COX-2 in tumour endothelium
T. Kurosu et al.
BRITISH JOURNAL OF CANCER (2011)
Glycolytic Phenotype and AMP Kinase Modify the Pathologic Response of Tumor Xenografts to VEGF Neutralization
Giorgia Nardo et al.
CANCER RESEARCH (2011)
Lactate: A Metabolic Key Player in Cancer
Franziska Hirschhaeuser et al.
CANCER RESEARCH (2011)
Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF-κB/IL-8 Pathway that Drives Tumor Angiogenesis
Frederique Vegran et al.
CANCER RESEARCH (2011)
Epigenetic mechanisms in diabetic vascular complications
Marpadga A. Reddy et al.
CARDIOVASCULAR RESEARCH (2011)
Basic and Therapeutic Aspects of Angiogenesis
Michael Potente et al.
CELL (2011)
Impaired Insulin Signaling in Endothelial Cells Reduces Insulin-Induced Glucose Uptake by Skeletal Muscle
Tetsuya Kubota et al.
CELL METABOLISM (2011)
Altered Mitochondrial Dynamics Contributes to Endothelial Dysfunction in Diabetes Mellitus
Sherene M. Shenouda et al.
CIRCULATION (2011)
Repression of P66Shc Expression by SIRT1 Contributes to the Prevention of Hyperglycemia-Induced Endothelial Dysfunction
Shuang Zhou et al.
CIRCULATION RESEARCH (2011)
Angiogenic morphogenesis driven by dynamic and heterogeneous collective endothelial cell movement
Satoshi Arima et al.
DEVELOPMENT (2011)
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Annika Armulik et al.
DEVELOPMENTAL CELL (2011)
Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells
Luciano Pirola et al.
GENOME RESEARCH (2011)
The role of oxidative stress in the pathophysiology of hypertension
Ramon Rodrigo et al.
HYPERTENSION RESEARCH (2011)
Signal transduction in vasculogenesis and developmental angiogenesis
Sunita Patel-Hett et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2011)
De Novo Lipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation
Xiaochao Wei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells FROM ENTRY OF EXTRACELLULAR PRECURSORS TO MITOCHONDRIAL NAD GENERATION
Andrey Nikiforov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Insulin-Stimulated L-Arginine Transport Requires SLC7A1 Gene Expression and Is Associated With Human Umbilical Vein Relaxation
Marcelo Gonzalez et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2011)
eNOS activation and NO function: Structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity
Ruslan Rafikov et al.
JOURNAL OF ENDOCRINOLOGY (2011)
Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet et al.
NATURE (2011)
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Heribert Schunkert et al.
NATURE GENETICS (2011)
Requirement of argininosuccinate lyase for systemic nitric oxide production
Ayelet Erez et al.
NATURE MEDICINE (2011)
Tumor angiogenesis: molecular pathways and therapeutic targets
Sara M. Weis et al.
NATURE MEDICINE (2011)
The lymphatic vasculature in disease
Kari Alitalo
NATURE MEDICINE (2011)
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
Mark E. Lobatto et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)
Xiangyu Liu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
A local glucose-and oxygen concentration-based insulin secretion model for pancreatic islets
Peter Buchwald
THEORETICAL BIOLOGY AND MEDICAL MODELLING (2011)
Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells
Iwona Fijalkowska et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
Hypoxic upregulation of arginase II in human lung endothelial cells
Karina Krotova et al.
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Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE(-/-) mice
Courtney P. Judkins et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)
Critical role for lactate dehydrogenase A in aerobic glycolysis that sustains pulmonary microvascular endothelial cell proliferation
Glenda Parra-Bonilla et al.
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Role of Mitochondrial DNA Damage in the Development of Diabetic Retinopathy, and the Metabolic Memory Phenomenon Associated with Its Progression
Sally A. Madsen-Bouterse et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Human Exercise-Induced Circulating Progenitor Cell Mobilization Is Nitric Oxide-Dependent and Is Blunted in South Asian Men
Richard M. Cubbon et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)
Isolated tumor endothelial cells maintain specific character during long-term culture
Kohei Matsuda et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Filamentous actin and its associated binding proteins are the stimulatory site for 6-phosphofructo-1-kinase association within the membrane of human erythrocytes
Antonio Real-Hohn et al.
BIOCHIMIE (2010)
KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium
Reinier A. Boon et al.
BLOOD (2010)
Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching
Geraldine A. Strasser et al.
BLOOD (2010)
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
Alessandro Fantin et al.
BLOOD (2010)
Preventive effects of pravastatin on thrombin-triggered vascular responses via Akt/eNOS and RhoA/Rac1 pathways in vivo
Hiroshi Ohkawara et al.
CARDIOVASCULAR RESEARCH (2010)
Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease
Sara Van de Veire et al.
CELL (2010)
Ketones and lactate fuel tumor growth and metastasis Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
Gloria Bonuccelli et al.
CELL CYCLE (2010)
GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries
Brandon S. J. Davies et al.
CELL METABOLISM (2010)
Loss of Insulin Signaling in Vascular Endothelial Cells Accelerates Atherosclerosis in Apolipoprotein E Null Mice
Christian Rask-Madsen et al.
CELL METABOLISM (2010)
Oxidative Stress and Diabetic Complications
Ferdinando Giacco et al.
CIRCULATION RESEARCH (2010)
The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating DII4/Notch Signaling
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Functional Role of HSP90 Complexes with Endothelial Nitric-oxide Synthase (eNOS) and Calpain on Nitric Oxide Generation in Endothelial Cells
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Interleukin (IL) 1β induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IκB kinase α pathway targeting activator protein-1
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Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
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Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasis
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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
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Atherosclerosis is attenuated by limiting superoxide generation in both macrophages and vessel wall cells
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Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism
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Immunochemical crossreactivity of antibodies specific for advanced glycation endproducts with advanced lipoxidation endproducts
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被撤回的出版物: Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma (Retracted article. See vol. 293, pg. 18014, 2018)
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Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells - Efficacy of combined cell and eNOS gene therapy in established disease
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Structure-based discovery of human L-xylulose reductase inhibitors from database screening and molecular docking
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Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1
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Oxidative stress in severe pulmonary hypertension
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Lactate in solid malignant tumors: Potential basis of a metabolic classification in clinical oncology
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CURRENT MEDICINAL CHEMISTRY (2004)
Tumor-associated endothelial cells with cytogenetic abnormalities
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Why do cancers have high aerobic glycolysis?
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Nitric oxide and pulmonary arterial pressures in pulmonary hypertension
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FREE RADICAL BIOLOGY AND MEDICINE (2004)
Pulsatile versus oscillatory shear stress regulates NADPH oxidase subunit expression -: Implication for native LDL oxidation
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Human glycated albumin affects glucose metabolism in L6 skeletal muscle cells by impairing insulin-induced insulin receptor substrate (IRS) signaling through a protein kinase Cα-mediated mechanism
C Miele et al.
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Molecular distinction between arteries and veins
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A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidase
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CURRENT MEDICINAL CHEMISTRY (2003)
Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis
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Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine
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Aging, progenitor cell exhaustion, and atherosclerosis
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VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
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Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization
T Kondo et al.
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Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
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Glutamine and glutamate - their central role in cell metabolism and function
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Abnormal angiogenesis in diabetes mellitus
A Martin et al.
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Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide
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ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2003)
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy
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NATURE MEDICINE (2003)
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NEW ENGLAND JOURNAL OF MEDICINE (2003)
Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB-C/EBP-β complex formation
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Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells
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Role of reactive oxygen species in vascular remodeling associated with pulmonary hypertension
S Wedgwood et al.
ANTIOXIDANTS & REDOX SIGNALING (2003)
Molecular understanding of hyperglycemia's adverse effects for diabetic complications
MJ Sheetz et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2002)
Human endothelial progenitor exhibit impaired proliferation, cells from type II diabetics adhesion, and incorporation into vascular structures
OM Tepper et al.
CIRCULATION (2002)
Dossier:: Free amino acids in human health and pathologies -: I.: Arginine
H Tapiero et al.
BIOMEDICINE & PHARMACOTHERAPY (2002)
Dossier:: Free amino acids in human health and pathologies -: II.: Glutamine and glutamate
H Tapiero et al.
BIOMEDICINE & PHARMACOTHERAPY (2002)
Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate
YK Hong et al.
DEVELOPMENTAL DYNAMICS (2002)
Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice
HC Champion et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
GJPL Kops et al.
NATURE (2002)
Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor
TV Petrova et al.
EMBO JOURNAL (2002)
Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells
M Federici et al.
CIRCULATION (2002)
Different effects of glucose starvation on expression and stability of VEGF mRNA Isoforms in murine ovarian cancer cells
L Zhang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Mechanisms of increased vascular superoxide production in human diabetes mellitus Role of NAD(P)H oxidase and endothelial nitric oxide synthase
TJ Guzik et al.
CIRCULATION (2002)
Endothelial cells derived from human embryonic stem cells
S Levenberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
JT Wigle et al.
EMBO JOURNAL (2002)
Xanthine oxidase is involved in free radical production in type 1 diabetes -: Protection by allopurinol
MC Desco et al.
DIABETES (2002)
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
S Nemoto et al.
SCIENCE (2002)
Insulin causes endothelial dysfunction in humans - Sites and mechanisms
G Arcaro et al.
CIRCULATION (2002)
Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR
R Colavitti et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells
M Montagnani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Hypoxia - A key regulatory factor in tumour growth
AL Harris
NATURE REVIEWS CANCER (2002)
Mitochondrial coupling factor 6 is present on the surface of human vascular endothelial cells and is released by shear stress
T Osanai et al.
CIRCULATION (2001)
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
XL Du et al.
JOURNAL OF CLINICAL INVESTIGATION (2001)
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
T Mäkinen et al.
EMBO JOURNAL (2001)
Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser1179
M Montagnani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Peripheral arterial disease in diabetic and nondiabetic patients - A comparison of severity and outcome
EB Jude et al.
DIABETES CARE (2001)
Acute regulation of fatty acid oxidation and AMP-activated protein kinase in human umbilical vein endothelial cells
Z Dagher et al.
CIRCULATION RESEARCH (2001)
Presence of glutamine:fructose-6-phosphate amidotransferase for glucosamine-6-phosphate synthesis in endothelial cells:: effects of hyperglycaemia and glutamine
G Wu et al.
DIABETOLOGIA (2001)
Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase
M Ishii et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2001)
High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells
ZQ Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Oncogenes and angiogenesis: Signaling three-dimensional tumor growth
J Rak et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS (2000)
Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors
J Yamashita et al.
NATURE (2000)
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
T Inoguchi et al.
DIABETES (2000)
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation
XL Du et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Angiogenesis in cancer and other diseases
P Carmeliet et al.
NATURE (2000)
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
IM Stratton et al.
BMJ-BRITISH MEDICAL JOURNAL (2000)
LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells -: Involvement of S-adenosylmethionine-dependent methyltransferases
RH Böger et al.
CIRCULATION RESEARCH (2000)
A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall
A Görlach et al.
CIRCULATION RESEARCH (2000)
Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
GY Zeng et al.
CIRCULATION (2000)
Endothelin 1 transcription is controlled by nuclear factor-kappa B in AGE-stimulated cultured endothelial cells
P Quehenberger et al.
DIABETES (2000)
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