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A Small-Molecule Inducer of the Antioxidant Response Element
Wooyoung Hur et al.
CHEMISTRY & BIOLOGY (2010)
p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
Ashish Jain et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
4-Hydroxy-2-nonenal protects against cardiac ischemia-reperfusion injury via the Nrf2-dependent pathway
Yan Zhang et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)
NFE2L2 Gene Mutation in Male Japanese Squamous Cell Carcinoma of the Lung
Hidefumi Sasaki et al.
JOURNAL OF THORACIC ONCOLOGY (2010)
A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
Alexandria Lau et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Masaaki Komatsu et al.
NATURE CELL BIOLOGY (2010)
An internal ribosomal entry site mediates redox-sensitive translation of Nrf2
Wenge Li et al.
NUCLEIC ACIDS RESEARCH (2010)
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
Deepti Malhotra et al.
NUCLEIC ACIDS RESEARCH (2010)
Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial
Ory Keynan et al.
PAIN MEDICINE (2010)
Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial KATP channels
Cheng Shi Piao et al.
PHARMACOLOGICAL RESEARCH (2010)
Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver
Curtis D. Klaassen et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)
Nrf2 protects against airway disorders
Hye-Youn Cho et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2010)
PYDDT, a novel phase 2 enzymes inducer, activates Keap1-Nrf2 pathway via depleting the cellular level of glutathione
Xiaoyu Zhang et al.
TOXICOLOGY LETTERS (2010)
Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State
Mustafa Zakkar et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)
How mitochondria produce reactive oxygen species
Michael P. Murphy
BIOCHEMICAL JOURNAL (2009)
Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
Chenhui Yang et al.
BRAIN RESEARCH (2009)
Prospective, Comprehensive Assessment of Cardiac Troponin T Testing After Coronary Artery Bypass Graft Surgery
Asim A. Mohammed et al.
CIRCULATION (2009)
Troponin is superior to electrocardiogram and creatinine kinase MB for predicting clinically significant myocardial injury after coronary artery bypass grafting
Jochen D. Muehlschlegel et al.
EUROPEAN HEART JOURNAL (2009)
Targeting the Nrf2 pathway against cardiovascular disease
Jinqing Li et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2009)
The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress
Truyen Nguyen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes
Xiaoqing He et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)
Declining In-Hospital Mortality and Increasing Heart Failure Incidence in Elderly Patients With First Myocardial Infarction
Justin A. Ezekowitz et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2009)
Dihydro-CDDO-Trifluoroethyl Amide (dh404), a Novel Nrf2 Activator, Suppresses Oxidative Stress in Cardiomyocytes
Tomonaga Ichikawa et al.
PLOS ONE (2009)
Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells
Aruna Kode et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2008)
Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries
John D. Groopman et al.
ANNUAL REVIEW OF PUBLIC HEALTH (2008)
Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis
Wenge Li et al.
BIOCHEMICAL PHARMACOLOGY (2008)
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
Xiao-Jun Wang et al.
CARCINOGENESIS (2008)
Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1
Claude A. Piantadosi et al.
CIRCULATION RESEARCH (2008)
PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
Shih-Ching Lo et al.
EXPERIMENTAL CELL RESEARCH (2008)
Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds
Keisuke Yamamoto et al.
JOURNAL OF BIOCHEMISTRY (2008)
GSK-3β down-regulates the transcription factor Nrf2 after oxidant damage:: relevance to exposure of neuronal cells to oxidative stress
Ana I. Rojo et al.
JOURNAL OF NEUROCHEMISTRY (2008)
The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis
Weihua Xu et al.
LABORATORY INVESTIGATION (2008)
Disruption of Nrf2, a Key Inducer of Antioxidant Defenses, Attenuates ApoE-Mediated Atherosclerosis in Mice
Thomas E. Sussan et al.
PLOS ONE (2008)
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
Tatsuhiro Shibata et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Different electrostatic Potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
Kit I. Tong et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Translational control of Nrf2 protein in activation of antioxidant response by oxidants
Sally E. Purdom-Dickinson et al.
MOLECULAR PHARMACOLOGY (2007)
Biomechanical forces in atherosclerosis-resistant vascular regions regulate endothelial redox balance via phosphoinositol 3-kinase/akt-dependent activation of Nrf2
Guohao Dai et al.
CIRCULATION RESEARCH (2007)
Mechanisms of disease: Myocardial reperfusion injury
Derek M. Yellon et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
XANTHINE OXIDASE AS A MARKER OF MYOCARDIAL INFARCTION
Rashmi Raghuvanshi et al.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY (2007)
Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways
Ping Yao et al.
JOURNAL OF HEPATOLOGY (2007)
Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury
Narasimman Gurusamy et al.
FREE RADICAL BIOLOGY AND MEDICINE (2007)
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
Jacqui M. Marzec et al.
FASEB JOURNAL (2007)
Nrf2 is involved in the effect of tanshinone IIA on intracellular redox status in human aortic smooth muscle cells
Hong-Sheng Zhang et al.
BIOCHEMICAL PHARMACOLOGY (2007)
Bis(2-hydroxybenzylidene) acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway
Albena T. Dinkova-Kostova et al.
CANCER LETTERS (2007)
Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: Evidence from gene expression profiling and activation of Nrf2 transcription factor
Sally E. Purdom-Dickinson et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2007)
Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes
Melinda S. Yates et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism
Kit I. Tong et al.
BIOLOGICAL CHEMISTRY (2006)
Global translational responses to oxidative stress impact upon multiple levels of protein synthesis
Daniel Shenton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a Tethering mechanism - A two-site interaction model for the Nrf2-Keap1 complex
Michael McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Glycogen synthase kinase-3β inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2
Maria Salazar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
KI Tong et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Trends in five-year survival of patients discharged after acute myocardial infarction
IR Bata et al.
CANADIAN JOURNAL OF CARDIOLOGY (2006)
Nrf2: A potential molecular target for cancer chemoprevention by natural compounds
WS Jeong et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Antioxidants and phase 2 enzymes in cardiomyocytes: Chemical inducibility and chemoprotection against oxidant and simulated ischemia-reperfusion injury
Zhuoxiao Cao et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2006)
Oltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA
YL Chua et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice
GX Shen et al.
PHARMACEUTICAL RESEARCH (2005)
NF-κB, Nrf2, and HO-1 interplay in redox-regulated VCAM-1 expression
A Banning et al.
ANTIOXIDANTS & REDOX SIGNALING (2005)
Internal ribosome entry sites in cellular mRNAs: Mystery of their existence
AA Komar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Role of Nrf2 signaling in regulation of antioxidants and phase 2 enzymes in cardiac fibroblasts: Protection against reactive oxygen and nitrogen species-induced cell injury
H Zhu et al.
FEBS LETTERS (2005)
Interspecies pharmacokinetic scaling of oltipraz in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics
SK Bae et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2005)
Translational control in stress and apoptosis
M Holcik et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts
S Purdom et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
JH Suh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Transcription factor nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
GK McWalter et al.
JOURNAL OF NUTRITION (2004)
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H: quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence
P Nioi et al.
BIOCHEMICAL JOURNAL (2003)
Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning
ZQ Zhao et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
M McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Curcurnin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
E Balogun et al.
BIOCHEMICAL JOURNAL (2003)
Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis
JM Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles
K Itoh et al.
GENES TO CELLS (2003)
Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element - Degradation of Nrf2 by the 26 S proteasome
T Nguyen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium
D Stewart et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Nrf2 degradation by the ubiquitin proteasome pathway is inhibited by KIAA0132, the human homolog to INrf2
KR Sekhar et al.
ONCOGENE (2002)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound
S Braun et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents:: Role of antioxidant response element-like sequences in the nrf2 promoter
MK Kwak et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Signals of oxidant-induced cardiomyocyte hypertrophy: Key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase
VC Tu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
An important function of Nrf2 in combating oxidative stress: Detoxification of acetaminophen
KM Chan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
M Ramos-Gomez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Elevated cardiac troponin levels predict the risk of adverse outcome in patients with acute coronary syndromes
F Ottani et al.
AMERICAN HEART JOURNAL (2000)
Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-κB pathway
S Basu et al.
INTERNATIONAL IMMUNOLOGY (2000)
Visualisation of cell death in vivo in patients with acute myocardial infarction
L Hofstra et al.
LANCET (2000)
Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
T Ishii et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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