期刊
PHYSIOLOGICAL GENOMICS
卷 50, 期 9, 页码 691-693出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiolgenomics.00145.2017
关键词
COL1A1 single nucleotide polymorphism (SNP); COL5A1 gene; delayed-onset muscle soreness (DOMS) phenotype; exercise-induced muscle damage (EIMD); lateral force transmission
资金
- Liverpool John Moores University
We investigated whether single nucleotide polymorphisms (SNPs) within genes encoding the alpha-1 chain of type I (COL1A1, rs2249492; rs1800012), type II (COL2A1, rs2070739), and type V (COL5A1, rs12722) collagen were associated with the variable response to exercise-induced muscle damage (EIMD). Knee extensor muscle strength and soreness were assessed pre-, post-, and 48 h post-EIMD (120 maximal eccentric knee extensor contractions) in 65 young healthy participants, who were geno-typed for the aforementioned SNPs. We found that COL1A1 (minor) T-allele carriers (rs1800012) and (major) T-allele homozygotes (rs2249492) were generally weaker (P <= 0.019); and (minor) A-allele carriers of COL2A1 (P <= 0.002) and (major) T-allele carriers of COL5A1 (P <= 0.004) SNPs reported greater muscle soreness, all compared with their respective major (rs1800012; rs2070739) and minor (rs2249492; rs12722) allele homozygote counterparts. To conclude, the risk alleles of these four SNPs appear to negatively influence muscle strength and post-EIMD recovery, possibly via a dysregulated collagen network affecting the muscle's mechanical properties.
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