期刊
PHYSICAL REVIEW LETTERS
卷 120, 期 12, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevLett.120.128102
关键词
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资金
- AGAUR
- MINECO [MTM2015-71509-C2-1-R]
- CERCA Program of the Generalitat de Catalunya
- AGAUR [2014SGR1307]
- Wellcome Trust [WT098325MA]
- MINECO (CRM-BGSMath Maria de Maeztu program) [MDM-2014-0445]
- Wellcome Trust [098325/Z/12/Z] Funding Source: researchfish
Cell state determination is the outcome of intrinsically stochastic biochemical reactions. Transitions between such states are studied as noise-driven escape problems in the chemical species space. Escape can occur via multiple possible multidimensional paths, with probabilities depending nonlocally on the noise. Here we characterize the escape from an oscillatory biochemical state by minimizing the Freidlin-Wentzell action, deriving from it the stochastic spiral exit path from the limit cycle. We also use the minimized action to infer the escape time probability density function.
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