期刊
CHINESE JOURNAL OF NATURAL MEDICINES
卷 11, 期 2, 页码 188-192出版社
CHINESE JOURNAL NATURAL MEDICINES
DOI: 10.3724/SP.J.1009.2013.00188
关键词
Strictosamide; Vincoside lactam; Acid-catalyzed transformation
资金
- Eleventh Five-Year major projects for innovation of new drug candidates [2009ZX09013-379, 2012ZX09102201-017]
AIM: To identify the structure of the acid-catalyzed product of strictosamide and explore the reaction mechanism. METHODS: The acid-catalyzed reaction process of strictosamide was monitored by HPLC, and a macroporous resin was used to purify the reaction solution. The structure of the product was confirmed by MS, NMR, and ROESY spectra. RESULTS: The acid-catalyzed transformation yield from strictosamide to vincoside lactam was 52%. CONCLUSION: The reaction mechanism of the transformation from strictosamide to vincoside lactam may be related to the stability of the three-dimensional configuration of the compound. These results offer a new way to obtain vincoside lactam from the widely distributed indole alkaloid strictosamide by acid-catalysis.
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