期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 23, 期 -, 页码 50-54出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.pdpdt.2018.06.002
关键词
Magnetite-silica nanoparticls; Photodynamic therapy; Cytotoxicity; HepG2 cells; MCF-7 cells
类别
资金
- Natural Science Foundation of Shanxi Province [2012011005-8]
Core-shell magnetite-silica nanocomposites modified with 3-aminopropyltriethoxy silane (APTES) were prepared by silanization reaction, and characterized by X-ray diffraction, Fourier transform infrared spectroscopy, transmission electron microscopy and dynamic light scattering. Then the nanocomposites were employed as carriers of a photoactive platinum diimine complex. Photoinduced cytotoxicity by the photosensitizer-loaded nanocomposites in different human carcinoma cells has been studied by cell viability assay. The cellular uptake of the photosensitizer-loaded nanocomposites has also been studied by ICP-MS. The results suggest that the cytotoxicity induced by the platinum diimine complex in red light can be greatly enhanced when the photosensitizer is loaded with the magnetic nanocomposites, and the surface charge of the nanocomposites may also have effect on the photocytotoxicity of the photosensitizer.
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