期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 21, 期 -, 页码 43-49出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.pdpdt.2017.11.003
关键词
Cancer; PDT; Mesoporous silica; Nanoemulsion; Nanoparticle
类别
资金
- National Scientific and Technological Research Council (CNPQ)
- Rio de Janeiro State Research Foundation(FAPERJ)
- Ministerio de Economia y Competitividad [MAT2012-38429-004-01]
- GeneralitatValenciana [PROMETEO/2009/016]
The use of nanosystems as diagnosing and therapy systems is increasing each year. There are several nanosystems available and the most prominent ones are: mesoporous silica, nanoemulsion and polymeric nanoparticles. With characteristics like low toxicology, and easy -producing process they have advantages when compared with the traditional system used, as they show specific targeting, controlled release, and higher penetration. In this study we tested three different nanocarriers (polymeric nanoparticles, nanoemulsion and mesoporous silica) containing phthalocyanineas possible PDT drugs (nanodrugs). They were tested in vitro and in vivo: cells and healthy mice, respectively, in order to understand the biological behavior and reach the initial conclusions. The results in cells showed that a dose response was observed with different concentrations of the three nanocarriers. The results in animal showed that all nanosystems have potential for application in PDT, since they were able to produce a visible effect in healthy animals.
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