期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 373, 期 1741, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2016.0447
关键词
survival; longevity; systematic review; wild; publication bias
类别
资金
- Leverhulme Trust
- BBSRC responsive mode grant [BB/L020769/1]
- BBSRC through EASTBIO Doctoral Training Partnership [BB/J01446X/1]
- BBSRC [BB/L020769/1, BB/I02528X/1, BB/H021868/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I02528X/1, BB/L020769/1, BB/H021868/1] Funding Source: researchfish
Telomere length (TL) has become a biomarker of increasing interest within ecology and evolutionary biology, and has been found to predict subsequent survival in some recent avian studies but not others. Here, we undertake the first formal meta-analysis to test whether there is an overall association between TL and subsequent mortality risk in vertebrates other than humans and model laboratory rodents. We identified 27 suitable studies and obtained standardized estimates of the hazard ratio associated with TL from each. We performed a meta-analysis on these estimates and found an overall significant negative association implying that short telomeres are associated with increased mortality risk, which was robust to evident publication bias. While we found that heterogeneity in the hazard ratios was not explained by sex, follow-up period, maximum lifespan or the age group of the study animals, the TL-mortality risk association was stronger in studies using qPCR compared to terminal restriction fragment methodologies. Our results provide support for a consistent association between short telomeres and increased mortality risk in birds, but also highlight the need for more research into non-avian vertebrates and the reasons why different telomere measurement methods may yield different results.
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