期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 373, 期 1750, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2017.0216
关键词
pluripotent stem cells; organoids; three-dimensional culture
类别
资金
- NC3R SBRI CRACK-IT InMutagene award
- GSK
- Novartis
- Brunel University London Scholarship award
- UK Regenerative Medicine Platform [MRC MR/L022974/1]
- MRC [MR/L022974/1] Funding Source: UKRI
Recent advances in the isolation of tissue-resident adult stem cells and the identification of inductive factors that efficiently direct differentiation of human pluripotent stem cells along specific lineages have facilitated the development of high-fidelity modelling of several tissues in vitro. Many of the novel approaches have employed self-organizing three-dimensional (3D) culturing of organoids, which offer several advantages over conventional two-dimensional platforms. Organoid technologies hold great promise for modelling diseases and predicting the outcome of drug responses in vitro. Here, we outline the historical background and some of the recent advances in the field of three-dimensional organoids. We also highlight some of the current limitations of these systems and discuss potential avenues to further benefit biological research using three-dimensional modelling technologies. This article is part of the theme issue 'Designer human tissue: coming to a lab near you'.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据