期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 43, 期 5, 页码 1243-1247出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-012-1661-2
关键词
Antiepileptic; Anticonvulsant; Mood stabilizer; Sodium channel; Pervasive developmental disorder
We examined response to oxcarbazepine prescribed for irritability/agitation symptoms in a retrospective case series of 30 patients with Autism Spectrum Disorder (ASD). The average patient was 12.0 years old (range 5-21) and taking two other psychotropic medications (range 0-4). Fourteen patients (47 %) had a clinical global impression of improvement score of 'much improved' during treatment. Ten patients (33 %) showed an improvement on their clinical global impression of severity score. Seven patients (23 %) had a clinically significant adverse event or side effect leading to oxcarbazepine discontinuation. Without a placebo group, it is not possible to evaluate whether oxcarbazepine provides benefit for irritability/agitation symptoms in ASD. The high rate of adverse events suggests its use should be accompanied by caution.
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