期刊
PHARMACOGENOMICS
卷 19, 期 7, 页码 599-612出版社
FUTURE MEDICINE LTD
DOI: 10.2217/pgs-2018-0004
关键词
biomarkers; cardiovascular diseases; pharmacodynamics; pharmacogenomics
资金
- Pfizer
- Astra-Zeneca
- Roche
- Dalcor
- Novartis
- Servier
- Amarin
- EliLilly
- Esperion
- Merck
- Sanofi
Aim: To evaluate the impact of AGTR1 A1166C (rs5186) on the response to candesartan in patients with heart failure. Materials & methods: Prospective, multicentre, open-label study. We studied 299 symptomatic patients with heart failure presenting a left ventricular ejection fraction <= 40%. Results: Reductions in the primary end points of natriuretic peptides were not significantly associated with AGTR1 A1166C. Nevertheless, carrying the 1166C allele was associated with a greater compensatory increase in renin activity (p = 0.037) after 16 weeks of treatment with candesartan and a more modest effect on aldosterone concentrations (p = 0.022). Conclusion: AGTR1 1166C carriers may experience a greater long-term compensatory renin-angiotensin-aldosterone system activation following treatment with candesartan. Whether these associations ultimately influence clinical outcomes requires investigation.
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