期刊
PHARMACOGENOMICS
卷 19, 期 3, 页码 227-241出版社
FUTURE MEDICINE LTD
DOI: 10.2217/pgs-2017-0101
关键词
5-FU toxicity; allele frequency; DPYD; drug-related side effects and adverse reactions; pharmacogenomics; south Asia
资金
- Council of Scientific and Industrial Research (CSIR), through Wellness Genomics Project [BSC0212]
- CARDIOMED [BSC0122]
- GOMED [MLP1601]
Aim: Adverse drug reactions to 5-Fluorouracil(5-FU) is frequent and largely attributable to genetic variations in the DPYD gene, a rate limiting enzyme that clears 5-FU. The study aims at understanding the pharmacogenetic landscape of DPYD variants in south Asian populations. Materials & methods: Systematic analysis of population scale genome wide datasets of over 3000 south Asians was performed. Independent evaluation was performed in a small cohort of patients. Results: Our analysis revealed significant differences in the the allelic distribution of variants in different ethnicities. Conclusions: This is the first and largest genetic map the DPYD variants associated with adverse drug reaction to 5-FU in south Asian population. Our study highlights ethnic differences in allelic frequencies.
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