期刊
PHARMACEUTICAL BIOLOGY
卷 56, 期 1, 页码 287-293出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13880209.2018.1462834
关键词
Orthosiphon aristatus; Woodfordia floribunda; Rotheca serrata; antibacterial; anti-candidal
资金
- Erasmus Mundus project ALFABET (Asia: Life, Food, Agriculture, Biology, Economics, Technology) [55207]
- Czech University of Life Sciences Prague Grant Agency project CIGA [20175001]
- Internal Grant Agency project IGA [20175020]
Context: In many regions of Indonesia, there are numerous traditional herbal preparations for treatment of infectious diseases. However, their antimicrobial potential has been poorly studied by modern laboratory methods. Objective: This study investigates in vitro antimicrobial activity of 49 ethanol extracts from 37 plant species used in Indonesian traditional medicine for treatment against Candida albicans, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Materials and methods: The plants were collected from the Biopharmaca collection garden, Bogor, Indonesia. The plant material was dried, finely grounded, extracted using ethanol, concentrated, and the dried residue was dissolved in 100% DMSO. Antimicrobial activity was determined in terms of a minimum inhibitory concentration (MIC) using a broth microdilution method in 96-well microplates. Results: The extract of Orthosiphon aristatus (Blume) Miq. (Lamiaceae) leaf produced the strongest antimicrobial effect, inhibiting the growth of C. albicans (MIC 128 mu g/mL), S. aureus (MIC 256 mu g/mL), E. faecalis (MIC 256 mu g/mL) and P. aeruginosa (MIC 256 mu g/mL). The leaf extract of Woodfordia floribunda Salisb. (Lythraceae) also exhibited significant effect against C. albicans (MIC 128 mu g/mL), S. aureus (MIC 256 mu g/mL) and E. faecalis (MIC 256 mu g/mL). Rotheca serrata (L.) Steane & Mabb. (Lamiaceae) leaf extract inhibited the growth of S. aureus (MIC 256 mu g/mL) and C. albicans (MIC 256 mu g/mL). Discussion and conclusions: The leaf extract of O. aristatus and W. floribunda exhibited a significant anti-candidal effect. Therefore, both of these plants can serve as prospective source materials for the development of new anti-candidal agents.
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