期刊
PERSONALIZED MEDICINE
卷 15, 期 3, 页码 189-197出版社
FUTURE MEDICINE LTD
DOI: 10.2217/pme-2017-0094
关键词
analytical validation; combinatorial pharmacogenomics; genetic testing; neuropsychiatric conditions; pharmacogenomics
资金
- Assurex Health, a Myriad company
Aim: The aim of this study was to validate the analytical performance of a combinatorial pharmacogenomics test designed to aid in the appropriate medication selection for neuropsychiatric conditions. Materials & methods: Genomic DNA was isolated from buccal swabs. Twelve genes (65 variants/alleles) associated with psychotropic medication metabolism, side effects, and mechanisms of actions were evaluated by bead array, MALDI-TOF mass spectrometry, and/or capillary electrophoresis methods (GeneSight Psychotropic, Assurex Health, Inc.). Results: The combinatorial pharmacogenomics test has a dynamic range of 2.5-20 ng/mu l of input genomic DNA, with comparable performance for all assays included in the test. Both the precision and accuracy of the test were > 99.9%, with individual gene components between 99.4 and 100%. Conclusion: This study demonstrates that the combinatorial pharmacogenomics test is robust and reproducible, making it suitable for clinical use.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据