期刊
PEDIATRIC PULMONOLOGY
卷 53, 期 8, 页码 1018-1026出版社
WILEY
DOI: 10.1002/ppul.24067
关键词
25-hydroxyvitamin D; asthma; health services; preschool child; vitamin D
资金
- Ontario Lung Association, Ontario Thoracic Society
- Canadian Institutes for Health Research (CIHR)
- Institute of Human Development
- Child and Youth Health
- Institute of Nutrition, Metabolism and Diabetes [CIHR
- FRN-115059]
- St. Michael's Hospital Foundation [2012-0051-GF]
- Hospital for Sick Children Foundation [SP05-602]
BackgroundAsthma is the most common chronic illness of childhood and a common reason for hospital admission. Studies suggest that low vitamin D levels may be associated with health service utilization (HSU) for childhood asthma. The primary objective was to determine if vitamin D serum levels in early childhood were associated with HSU for asthma including: a) hospital admissions; b) emergency department visits; and c) outpatient sick visits. Secondary objectives were to determine whether vitamin D supplementation in pregnancy or childhood were associated with HSU for asthma. MethodsProspective cohort study of children participating in the TARGet Kids! practice-based research network between 2008 and 2013 in Toronto, Canada. HSU was determined by linking each child's provincial health insurance number to health administrative databases. Multivariable quasi-Poisson and logistic regression were used to evaluate the association between 25-hydroxyvitamin D concentrations, vitamin D supplementation in pregnancy, and childhood and HSU for asthma. ResultsA total of 2926 healthy children aged 0-6 years had 25-hydroxyvitamin D data available and were included in the primary analysis. Mean (IQR) 25-hydroxyvitmain D level was 84nmol/L (65-98nmol/L), 218 and 1267 children had 25-hydroxyvitamin D concentrations <50nmol/L and <75nmol/L, respectively. In the adjusted models, there were no associations between 25-hydroxyvitamin D concentrations (continuously or dichotomized at 50 and 75nmol/L), vitamin D supplementation in pregnancy or childhood and HSU for asthma. ConclusionsVitamin D blood values do not appear to be associated with HSU for asthma in this population of healthy urban children.
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