期刊
PEDIATRIC PULMONOLOGY
卷 53, 期 9, 页码 1231-1236出版社
WILEY
DOI: 10.1002/ppul.24076
关键词
lung ultrasonography; respiratory distress syndrome; surfactant therapy
ObjectivesWe aim to verify the diagnostic accuracy of a lung ultrasonography (LUS) score to early predict the need for surfactant therapy in newborns with respiratory distress syndrome (RDS), and to compare it with a chest X-ray score. MethodsIn this prospective diagnostic accuracy study we included all newborns admitted for respiratory distress and initially treated with nasal CPAP. LUS was performed within 2h from nasal CPAP positioning and in any case before surfactant administration. A chest X-ray was also performed. A LUS score and an X-ray score were used and compared. Ability of the scores to predict surfactant administration was evaluated through ROC analysis. ResultsIn our population of 56 newborns with mean gestational age of 31 weeks (SD 3) and mean birth weight of 1442g (SD 520), LUS score showed higher AUC than X-ray score in early recognition of infants with respiratory distress syndrome requiring surfactant treatment (0.94; 95%CI, 0.89-0.98; P<0.001 vs 0.80; 95%CI, 0.74-0.86; P<0.001). It showed also higher sensitivity (86% vs 82%), higher specificity (88% vs 76%), better positive (83% vs 69%), and negative (91% vs 87%) predictive values. ConclusionsLUS is a non-invasive, bedside and reproducible method that could improve the management of neonatal respiratory distress. It is accurate and reliable to early identify patients who will need treatment with surfactant allowing both an early treatment and a reduction of radiation exposure.
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