期刊
PEDIATRIC NEUROLOGY
卷 83, 期 -, 页码 42-49出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.pediatrneurol.2018.03.003
关键词
Optic neuritis; Pediatric; Neuromyelitis optics (NMO); Myelin oligodendrocyte glycoprotein (MOG); Aquaporin-4 (AQP4)
资金
- National Natural Science Foundation of China [81301027]
- Talent Doctor Project at Fudan University, Shanghai, China
Background: The clinical characteristics of patients with pediatric optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibodies in Asia have not been reported. Methods: Patients <= 18 years-old with acute-onset optic neuritis were enrolled. Serum myelin oligoden- drocyte glycoprotein and aquaporin-4 antibodies were detected and patients were followed for at least six months. The clinical features were evaluated among myelin oligodendrocyte glycoprotein-seropositive optic neuritis, aquaporin-4-seropositive optic neuritis, and double seronegative optic neuritis. Best-corrected visual acuity, thickness of optic disc retinal nerve fiber layer, and macular ganglion cell complex were measured by optical coherence tomography. Results: Among myelin oligodendrocyte glycoprotein optic neuritis, aquaporin 4 optic neuritis, and seronegative optic neuritis, the percentages of best-corrected visual acuity measured better than 0.8 (20/ 25) at the six-month visit were 89.47%, 33.33%, and 82.26%, respectively, a rate that is significantly better in patients with myelin oligodendrocyte glycoprotein optic neuritis and seronegative optic neuritis (P= 0.02). The average peripapillary retinal nerve fiber layers were 58.03 +/- 8.73 mu m, 64.34 +/- 12.88 mu m, and 78.12 +/- 13.34 mu m for the patients with myelin oligodendrocyte glycoprotein-optic neuritis, aquaporin-4-optic neuritis, and seronegative-optic neuritis, respectively, which showed no statistical difference between patients with myelin oligodendrocyte glycoprotein-optic neuritis and aquaporin-4-optic neuritis (P= 0.089), but were both thinner than patients with seronegative-optic neuritis (P = 0.001). Conclusions: The recovery of visual acuity in patients with myelin oligodendrocyte glycoprotein-optic neuritis was as good as in patients with seronegative-optic neuritis, and the retinal nerve fiber layer of the optic nerve head showed thinning as severe as that of the patients with aquaporin-4-optic neuritis. (C)2018 Elsevier Inc. All rights reserved.
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