Protective effect of the whole plant extract of Evolvulus alsinoides on glycoprotein alterations in streptozotocin induced diabetic rats

Objective To assess the effect of Evolvulus alsinoides (E. alsinoides) on glycoprotein levels in liver, kidney and pancreas of control and diabetes induced rats.Methods Wistar albino rats were used for the present study. The diabetes was induced by a single intraperitoneal injection of streptozotocin at 45 mg/kg body weight. After the induction of diabetes the rats were treated with glibenclamiede and E. alsinoides for 45 d. At the end of the experimental period the glycoprotein levels were estimated by using standard protocols.ResultsSignificantly higher levels of glycoproteins were observed in the tissues of diabetic rats when compared with the control rats. After treated with ethanolic extract of E. alsinoides and standard drug resulted in the reduction of glycoproteins when compared with the diabetic control rats.Conclusions The present study proved that that ethanolic extract of E. alsinoides owned a beneficial effect on glycoprotein components. Hence, it can be used in the prevention of glycoprotein medicated complications in diabetes mellitus.