期刊
PEDIATRIC BLOOD & CANCER
卷 65, 期 6, 页码 -出版社
WILEY
DOI: 10.1002/pbc.27008
关键词
bleomycin; sclerotherapy; vascular malformations
BackgroundVascular malformations (VM) are congenital lesions that can be debilitating and cause significant aesthetic and functional limitations. The chemotherapeutic agent bleomycin has been utilized as a sclerosant, directly injected percutaneously into the VM. Unfortunately, little is known about the benefits and short-term side effects of bleomycin with intralesional injections. ProcedureAn IRB approved, retrospective chart review was performed on patients with VM who had been treated with intralesional bleomycin. Data included type of VM, number of treatments, total bleomycin dose per m(2), and adverse effects. A questionnaire was administered to available patients to assess subjective outcomes and side effects. ResultsForty-six patients were treated with 141 procedures of bleomycin sclerotherapy for VM. Patient ages ranged from 1 to 20years (median age 10 years). The median cumulative bleomycin dose was 16.3units/m(2)/person (range of 1.7-97.0units/m(2)/person). Sixty-three percent of patients were reached for a questionnaire to assess short-term side effects. Ninety percent of patients surveyed were satisfied to very satisfied with the results from the procedure. About 24% of patients experienced transient nausea, vomiting and/or local hyperpigmentation. ConclusionBleomycin sclerotherapy can be an effective treatment of VM with repeat exposure with minor risk of short-term side effects, however, long-term risks are of great concern. Further studies are required to assess systemic absorption and long-term risks.
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