期刊
PEDIATRIC ANESTHESIA
卷 28, 期 6, 页码 528-536出版社
WILEY
DOI: 10.1111/pan.13390
关键词
children; cognitive outcomes; hospitalization; neurodevelopment; operative procedures; pediatric anesthetics
资金
- National Health and Medical Research Council [APP1047263]
- Dr Nassar National Health and Medical Research Council Career Development Fellowship [APP1067066]
- Dr Lain National Health and Medical Research Council Early Career Fellowship [APP1054571]
BackgroundThere has been considerable interest in the possible adverse neurocognitive effects of exposure to general anesthesia and surgery in early childhood. AimsThe aim of this data linkage study was to investigate developmental and school performance outcomes of children undergoing procedures requiring general anesthesia in early childhood. MethodsWe included children born in New South Wales, Australia of 37+ weeks' gestation without major congenital anomalies or neurodevelopmental disability with either a school entry developmental assessment in 2009, 2012, or Grade-3 school test results in 2008-2014. We compared children exposed to general anesthesia aged <48months to those without any hospitalization. Children with only 1 hospitalization with general anesthesia and no other hospitalization were assessed separately. Outcomes included being classified developmentally high risk at school entry and scoring below national minimum standard in school numeracy and reading tests. ResultsOf 211978 children included, 82156 had developmental assessment and 153025 had school test results, with 12848 (15.7%) and 25032 (16.4%) exposed to general anesthesia, respectively. Children exposed to general anesthesia had 17%, 34%, and 23% increased odds of being developmentally high risk (adjusted odds ratio [aOR]: 1.17; 95% CI: 1.07-1.29); or scoring below the national minimum standard in numeracy (aOR: 1.34; 95% CI: 1.21-1.48) and reading (aOR: 1.23; 95% CI: 1.12-1.36), respectively. Although the risk for being developmentally high risk and poor reading attenuated for children with only 1 hospitalization and exposure to general anesthesia, the association with poor numeracy results remained. ConclusionChildren exposed to general anesthesia before 4years have poorer development at school entry and school performance. While the association among children with 1 hospitalization with 1 general anesthesia and no other hospitalization was attenuated, poor numeracy outcome remained. Further investigation of the specific effects of general anesthesia and the impact of the underlying health conditions that prompt the need for surgery or diagnostic procedures is required, particularly among children exposed to long duration of general anesthesia or with repeated hospitalizations.
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