期刊
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
卷 35, 期 7, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppsc.201800148
关键词
melanoma; NAPamide; photothermal therapy
资金
- European Research Council (Advanced Grant VERDI
- ERC-2015-AdG) [694160]
- MINECO [MAT2015-64831-R, MAT2017-86659-R]
- Juan de la Cierva - Formacion 2014 program (FJCI-2014-2016)
- Alexander von Humboldt Foundation through a Feodor Lynen Fellowship
Melanoma is one of the most severe public health issues worldwide, not only because of the high number of cases but also for its poor prognosis in late stages. Therefore, early diagnosis and efficient treatment are key toward a future solution. However, melanoma is highly resistant to cytotoxicity in its metastatic form. In this context, a therapeutic strategy based on a targeted chemo-photothermal nanotransporter for cytotoxic compounds is proposed. This approach comprises the use of core-multishell gold nanorods, coated with mesoporous silica and further covered with a thermosensitive polymer, which is vectorized for selective internalization in melanoma cells. The proposed nanoformulation is capable of releasing the transported cytotoxic compounds on demand, in response to near-IR irradiation, with high selectivity and efficacy against malignant cells, even at low concentrations, thereby providing a new tool against melanoma disease.
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