期刊
PARASITOLOGY INTERNATIONAL
卷 67, 期 5, 页码 587-592出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.parint.2018.05.010
关键词
Toxoplasma gondii; Virulence; Atypical virulence; Genotype; Rhoptry protein
类别
资金
- Research Program on Emerging and Re-emerging Infectious Diseases from the Japan Agency for Medical Research and development (AMED) [16fk0108110j0001]
- Challenging Research (Pioneering) grant from the Japan Society for the Promotion of Science (JSPS) [17K19320]
- Grants-in-Aid for Scientific Research [17K19320] Funding Source: KAKEN
The virulence of a type III Toxoplasma gondii strain isolated in Japan and designated here as TgCatJpGil/TaJ was examined in mice and micro minipigs in this study. Despite its type III genotype, oral or intraperitoneal inoculation of cysts from it resulted in severe virulence in C57BL/6J and BALB/c mice. In contrast, mice inoculated with a high dose of TgCatJpGil/TaJ tachyzoites showed no obvious clinical signs of infection, and all of them survived for > 21 days post-inoculation. Furthermore, no clinical signs of infection were seen when micro minipigs were inoculated with 900 cysts. Interestingly, our allelic type screening of the virulence-related ropy, rop16, rop17, and rop18 genes, as based on restriction fragment length polymorphism analysis (RFLP), revealed that the RFLP patterns for TgCatJpGil/TaJ were identical to those from nonvirulent type III parasites. These results suggest that TgCatJpGil/TaJ possesses an unknown virulence factor or factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据