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Mee-Sup Yoon
NUTRIENTS (2017)
Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex
Jessica J. Howell et al.
CELL METABOLISM (2017)
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system
Sebastian I. Arriola Apelo et al.
AGING CELL (2016)
Potential therapeutic effects of mTOR inhibition in atherosclerosis
Ammar Kurdi et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2016)
Repurposing metformin: an old drug with new tricks in its binding pockets
Rosina Pryor et al.
BIOCHEMICAL JOURNAL (2015)
Altered Daytime Fluctuation Pattern of Plasminogen Activator Inhibitor 1 in Type 2 Diabetes Patients with Coronary Artery Disease: A Strong Association with Persistently Elevated Plasma Insulin, Increased Insulin Resistance, and Abdominal Obesity
Katarina Lalic et al.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2015)
Decreased Insulin Sensitivity and Impaired Fibrinolytic Activity in Type 2 Diabetes Patients and Nondiabetics with Ischemic Stroke
Aleksandra Jotic et al.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2015)
Rapamycin and Dietary Restriction Induce Metabolically Distinctive Changes in Mouse Liver
Zhen Yu et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2015)
Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway
Kumsun Cho et al.
SCIENTIFIC REPORTS (2015)
Metformin and respiratory chain complex I: the last piece of the puzzle?
Eric Fontaine
BIOCHEMICAL JOURNAL (2014)
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
Hannah R. Bridges et al.
BIOCHEMICAL JOURNAL (2014)
Strategies for the management of adverse events associated with mTOR inhibitors
Bruce Kaplan et al.
TRANSPLANTATION REVIEWS (2014)
Evidence for Rapamycin Toxicity in Pancreatic beta-Cells and a Review of the Underlying Molecular Mechanisms
Adam D. Barlow et al.
DIABETES (2013)
Can New-Onset Diabetes After Kidney Transplant Be Prevented?
Harini A. Chakkera et al.
DIABETES CARE (2013)
The multifaceted role of mTORC1 in the control of lipid metabolism
Stephane J. H. Ricoult et al.
EMBO REPORTS (2013)
Effectiveness and Long-Term Safety of Thiazolidinediones and Metformin in Renal Transplant Recipients
Binumol Kurian et al.
Endocrine Practice (2013)
Adverse events associated with mTOR inhibitors
Nicolas Pallet et al.
EXPERT OPINION ON DRUG SAFETY (2013)
Rapalogs and mTOR inhibitors as anti-aging therapeutics
Dudley W. Lamming et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
The Effect of mTOR-Inhibition on NF-κB Activity in Kidney Ischemia-Reperfusion Injury in Mice
A. Kezic et al.
TRANSPLANTATION PROCEEDINGS (2013)
Metformin improves healthspan and lifespan in mice
Alejandro Martin-Montalvo et al.
NATURE COMMUNICATIONS (2013)
Regulation of Immune Responses by mTOR
Jonathan D. Powell et al.
ANNUAL REVIEW OF IMMUNOLOGY, VOL 30 (2012)
Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
N. Deblon et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)
A. D. Barlow et al.
DIABETOLOGIA (2012)
Management of Metabolic Effects Associated With Anticancer Agents Targeting the PI3K-Akt-mTOR Pathway
Naifa L. Busaidy et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Activation of AMPK by the Putative Dietary Restriction Mimetic Metformin Is Insufficient to Extend Lifespan in Drosophila
Cathy Slack et al.
PLOS ONE (2012)
Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
Dudley W. Lamming et al.
SCIENCE (2012)
PI3K and mTOR Signaling Pathways in Cancer: New Data on Targeted Therapies
Lise Willems et al.
CURRENT ONCOLOGY REPORTS (2012)
Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
Lan Ye et al.
Frontiers in Genetics (2012)
If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
Vladimir N. Anisimov et al.
AGING-US (2011)
Activation of mTORC2 by Association with the Ribosome
Vittoria Zinzalla et al.
CELL (2011)
Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways
Jessica L. Yecies et al.
CELL METABOLISM (2011)
Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size
Yanyun Gu et al.
DIABETES (2011)
Reduced Risk of Colorectal Cancer With Metformin Therapy in Patients With Type 2 Diabetes A meta-analysis
Zhi-Jiang Zhang et al.
DIABETES CARE (2011)
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
X. Stephenne et al.
DIABETOLOGIA (2011)
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Peggy P. Hsu et al.
SCIENCE (2011)
Calorie restriction Decelerating mTOR-driven aging from cells to organisms (including humans)
Mikhail V. Blagosklonny
CELL CYCLE (2010)
Decreased IRS Signaling Impairs β-Cell Cycle Progression and Survival in Transgenic Mice Overexpressing S6K in β-Cells
Lynda Elghazi et al.
DIABETES (2010)
Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue
Vanessa P. Houde et al.
DIABETES (2010)
A complex interplay between Akt, TSC2 and the two mTOR complexes
Jingxiang Huang et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
Timothy R. Peterson et al.
CELL (2009)
New Users of Metformin Are at Low Risk of Incident Cancer A cohort study among people with type 2 diabetes
Gillian Libby et al.
DIABETES CARE (2009)
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Colin Selman et al.
SCIENCE (2009)
Immunoregulatory functions of mTOR inhibition
Angus W. Thomson et al.
NATURE REVIEWS IMMUNOLOGY (2009)
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Juan M. Garcia-Martinez et al.
BIOCHEMICAL JOURNAL (2008)
Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy
C. Florian Bentzinger et al.
CELL METABOLISM (2008)
The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response
Thomas Weichhart et al.
IMMUNITY (2008)
The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells
Sokol Haxhinasto et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Sirolimus is associated with new-onset diabetes in kidney transplant recipients
Olwyn Johnston et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
Sylvie Mordier et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
Frederic Tremblay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
AKT/PKB signaling: Navigating downstream
Brendan D. Manning et al.
CELL (2007)
The mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man
Michael Krebs et al.
DIABETES (2007)
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Zhihong Zeng et al.
BLOOD (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4(+) T cells, but enrich for antigen-specific Foxp3(+) T regulatory cells and promote organ transplant tolerance
Heth R. Turnquist et al.
JOURNAL OF IMMUNOLOGY (2007)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin
Thuy L. Phung et al.
CANCER CELL (2006)
Current development of mTOR inhibitors as anticancer agents
Sandrine Faivre et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Metformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscle
Cheryl A. Collier et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation
A Tzatsos et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Growing roles for the mTOR pathway
DD Sarbassov et al.
CURRENT OPINION IN CELL BIOLOGY (2005)
Identification of potential caloric restriction mimetics by microarray profiling
JM Dhahbi et al.
PHYSIOLOGICAL GENOMICS (2005)
Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
F Tremblay et al.
DIABETES (2005)
Metformin and reduced risk of cancer in diabetic patients
JMM Evans et al.
BMJ-BRITISH MEDICAL JOURNAL (2005)
Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway
M Ueno et al.
DIABETOLOGIA (2005)
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
L Khamzina et al.
ENDOCRINOLOGY (2005)
Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in β-cells
I Briaud et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
OJ Shah et al.
CURRENT BIOLOGY (2004)
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
SH Um et al.
NATURE (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
D Accili et al.
CELL (2004)
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
RM Anson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
SS Schaim et al.
CURRENT BIOLOGY (2003)
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
H Nojima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
DH Kim et al.
MOLECULAR CELL (2003)
Akt regulates growth by directly phosphorylating Tsc2
CJ Potter et al.
NATURE CELL BIOLOGY (2002)
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
R Loewith et al.
MOLECULAR CELL (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)
Metformin: An update
D Kirpichnikov et al.
ANNALS OF INTERNAL MEDICINE (2002)
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-Kinase/Akt pathway
BD Manning et al.
MOLECULAR CELL (2002)
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