期刊
OSTEOPOROSIS INTERNATIONAL
卷 29, 期 11, 页码 2505-2515出版社
SPRINGER LONDON LTD
DOI: 10.1007/s00198-018-4633-3
关键词
Fracture; Osteoporosis; SSRI; TBS; Trabecular bone score
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [R01AR59775, R01AR060574]
- Harvard Catalyst Clinical and Translational Science Center (CTSC) (NIH Award) [UL1 TR001102]
- Steve Cobb Junior Faculty and Fellow Education Fund
- [U01CA138962]
aSummaryWe investigated the association of clinical variables with TBS at baseline in the bone health sub-cohort of the VITamin D and OmegA-3 TriaL (VITAL). Lower TBS was associated with female sex, aging, BMI25kg/m(2), SSRI use, high alcohol intake, and presence of diabetes; there was a trend towards significance between lower TBS and history of fragility fractures.IntroductionWe investigated whether TBS differs by sex, race, body mass index (BMI), and other clinical variables.MethodsThe VITamin D and OmegA-3 TriaL (VITAL) is determining effects of vitamin D-3 and/or omega-3 fatty acid (FA) supplements in reducing risks of cancer and cardiovascular disease. In the VITAL: Effects on Bone Structure/Architecture ancillary study, effects of these interventions on bone will be investigated. Here, we examine the associations of clinical risk factors with TBS assessments at baseline in the bone health sub-cohort, comprised of 672 participants (369 men and 303 women), mean (SD) age 63.56.0years; BMI37kg/m(2), no bisphosphonates within 2years or other bone active medications within 1year.ResultsTBS was greater in men than women (1.311 vs. 1.278, P<0.001) and lower with elevated BMIs (P<0.001), higher age (P=0.004), diabetes (P=0.008), SSRI use (P=0.044), and high alcohol intake (P=0.009). There was a trend for history of fragility fractures (P=0.072), and lower TBS. TBS did not vary when analyzed by race, smoking, history of falls, and multivitamin or caffeine use.Conclusions Lower TBS was associated with female sex, aging, BMI25kg/m(2), SSRI use, alcohol use, and presence of diabetes; there was a trend between lower TBS and history of fragility fractures. TBS may be useful clinically to assess structural changes that may be associated with fractures among patients who are overweight or obese, those on SSRIs, or with diabetes. Ongoing follow-up studies will clarify the effects of supplemental vitamin D-3 and/or FA's on TBS and other bone health measures.Trial registrationNCT01747447
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