期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 22, 期 2, 页码 147-155出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.7b00318
关键词
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资金
- Horizon : Marie Skolodowska-Curie Individual Fellowship [659233]
- Marie Curie Actions (MSCA) [659233] Funding Source: Marie Curie Actions (MSCA)
Herewith a new process concept for synthesis is presented which combines both UV-photoirradiation and high-p,T intensification (photo-high-p,T) in continuous flow. The application of this procedure to Vitamin D-3 synthesis promotes thermal shifting of the equilibrium from the reaction intermediate to the product. This is enabled by microreactors which allow operation under harsh conditions such as the high temperature used here. This provides, to our best knowledge, a new kind of process combination (novel process window). As a result, in less than 1 min, 42% conversion of 7-dehydrocholesterol can be achieved giving a 17% yield and 40% selectivity of Vitamin D-3. This approach enhances productivity by up to 2 orders of magnitude compared with the current capillary based vitamin D-3 synthesis, because, under the microflow conditions, photochemistry can be performed at fairly high concentration and up to 20 times faster.
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