期刊
ORGANIC LETTERS
卷 20, 期 14, 页码 4267-4272出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01696
关键词
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资金
- National Natural Science Foundation of China [21702056, 21605070]
- National Program for Thousand Young Talents of China
- Fundamental Research Funds for the Central Universities
- State Key Laboratory of Analytical Chemistry for Life Science [SKLACLS1505]
A general and efficient protocol was developed for the synthesis of aryl alkyl ethers through metal-free C-OMe bond cleavage under mild reaction conditions. This process displays a wide scope of methoxyarenes and alcohols, including primary, secondary, and tertiary alcohols, as well as natural products, pharmaceuticals, and biologically active alcohols. DFT calculations and experimental results simultaneously confirm that a potassium ion plays a critical role in the activation of methoxy group via binding with the nitrile and provide support for an SNAr mechanism.
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