期刊
ORGANIC LETTERS
卷 20, 期 8, 页码 2485-2489出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b00870
关键词
-
资金
- NSFC [21672197, 21772184, 21502183]
- Chinese Academy of Science [XDB20000000]
A palladium(II)-catalyzed asymmetric 1,2-diamination of 1,3-dienes with readily available dialkylureas was established by using a chiral pyridine oxazoline ligand. The diamination reaction exclusively occurs at the terminal C-C double bond of the 1,3-dienes to give 4-vinylimidazolidin-2-ones in high yields and with excellent levels of enantioselectivity (up to 99% yield, 97% ee). The reaction could feasibly be applied for gram-scale synthesis with a 1:1 ratio of the diene and the urea.
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