期刊
ORGANIC LETTERS
卷 20, 期 13, 页码 4111-4115出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01667
关键词
-
资金
- SERB, India [EMR/2014/000207]
- IIT Gandhinagar
The first catalytic approach for the asymmetric synthesis of 3,4-disubstituted cyclohexadiene carbaldehydes through an inverse-electron demand Diels-Alder reaction is described. A variety of arylacetaldehydes and alpha,beta,gamma,delta-unsaturated aldehydes are tested under the mild reaction conditions catalyzed by L-proline to obtain the trans diastereomeric products with good yields and high enantioselectivities. The scope of this methodology is further extended to the asymmetric synthesis 3,4-disubstituted cyclohexane carbaldehydes and their derivatives. The practicality of this method is demonstrated by the gram-scale synthesis. This methodology is successfully applied for the formal total synthesis of cyclobakuchiol A, an antipyretic and anti-inflammatory agent, and cyclobakuchiol C.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据