4.8 Article

Enantioselective Decarboxylative Propargylation/Hydroamination Enabled by Organo/Metal Cooperative Catalysis

期刊

ORGANIC LETTERS
卷 20, 期 9, 页码 2792-2795

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01101

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资金

  1. NSFC [21702199]
  2. China Postdoctoral Science Foundation [2017M612075]

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The first catalytic enantioselective decarboxylative propargylation/hydroamination reaction of ethynyl benzoxazinanones with malononitriles enabled by organo/copper cooperative catalysis was established. Various 3-indolin-malononitrile derivatives, displaying a high tolerance for functional groups, could be obtained in good yields with high levels of enantioselectivity (up to 85% yield, 96:4 er). More importantly, this organo/metal cooperative catalytic system will provide a powerful synthetic strategy for new reaction development.

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