4.8 Article

Synthesis of 5-(Trifluoromethyl)pyrazolines by Formal [4+1]-Annulation of Fluorinated Sulfur Ylides and Azoalkenes

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ORGANIC LETTERS
卷 20, 期 4, 页码 934-937

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03811

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资金

  1. National Natural Science Foundation of China [21602025, 21302236]
  2. Foundation of Chongqing Science & Technology Commission [cstc2015jcyjA10086]
  3. Fundamental Research Funds for the Central Universities [CDJRC 11220001, 106112016CDJXY220004]

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In situ formed 1,2-diaza-1,3-dienes were used in formal [4 + 1]-annulation reactions with fluorinated sulfur ylides. This protocol provides a novel and efficient method for the synthesis of 5-(trifluoromethyl)pyrazolines in moderate to excellent yields.

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