期刊
ORGANIC LETTERS
卷 20, 期 10, 页码 3124-3127出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01215
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-
资金
- CAMS Innovation Fund for Medical Science [CIFMS: 2016-I2M-1-010]
Heliojatrones A and B (1 and 2), two jatrophane-derived diterpenoids with an unprecedented trans-bicyclo[8.3.0]tridecane core, were isolated from the whole plants of Euphorbia helioscopia. Their structures and absolute configurations were unequivocally determined by a combination of spectroscopic data, electronic circular dichroism calculations, biomimetic conversion, and X-ray diffraction analyses. Their plausible biosynthetic pathways were also proposed. Compounds 1 and 2 were biomimetically synthesized from 3 and 4 through a photochemical rearrangement reaction of beta, gamma -unsaturated ketone, respectively. Compound 2 showed significant P-glycoprotein inhibitory activity compared with the positive control (cydosporine A).
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