4.8 Article

Diastereoselective Synthesis of Polycyclic Indolizines with 2-(2-Enynyl)pyridines and Enamines

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ORGANIC LETTERS
卷 20, 期 12, 页码 3691-3694

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b01498

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  1. Swedish Research Council

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A diastereoselective metal-catalyzed reaction of 2-(2-enynyl)pyridines and cyclic enamines is reported. The method provides access to a variety of substituted indolizine derivatives by variation of the enyne component and the reaction conditions. Performing the reaction using a preformed enamine led to the formation of polycyclic indolizines. With in situ generated enamines, ketone-containing indolizine derivatives were obtained. An asymmetric reaction of 2-(2-enynyl)pyridines and enamines generated from an aldehyde and a catalytic amount of amine is presented.

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