期刊
ORGANIC LETTERS
卷 20, 期 4, 页码 1023-1026出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03968
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资金
- DST [EMR/2014/000225]
The first catalytic enantioselective nitroso aldol reaction of distal dialdehydes is reported. The reaction is catalyzed by simple l-proline at room temperature and subsequent reduction delivered biologically potent and synthetically versatile N-O bond containing five- and six-membered heterocycles, 1,2-oxazinanes, and isoxazolidines in high yields and excellent enantioselectivities (up to >99% ee). The method was further exploited to prepare chiral 3-hydroxypiperidines and -pyrrolidines that are otherwise difficult to access.
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