期刊
ORGANIC LETTERS
卷 20, 期 3, 页码 728-731出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03862
关键词
-
资金
- Russian Science Foundation [15-13-00092]
- Russian Science Foundation [15-13-00092] Funding Source: Russian Science Foundation
A highly expedient protocol for a catalytic Appel-type dehydration of amides to nitriles has been developed that employs oxalyl chloride and triethylamine along with triphenylphosphine oxide as a catalyst. The reactions are usually complete in less than 10 min with only a 1 mol % catalyst loading. The reaction scope includes aromatic, heteroaromatic, and aliphatic amides, including derivatives of alpha-hydroxy and alpha-amino acids.
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