期刊
ORGANIC LETTERS
卷 20, 期 3, 页码 732-735出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03865
关键词
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资金
- National Natural Science Foundation of China [21772044]
- National Young Top-Notch Talent Support Program
- Fundamental Research Funds for the Central Universities
- China Postdoctoral Science Foundation [2017M611490]
The first total synthesis of (-)-xestosaprol N and O is described. This synthetic work features a convergent strategy: (1) a Pd-catalyzed arylation followed by cyclization to build a naphthalene fragment (ring C, D); (2) utilization of (-)-quint acid to construct the chiral hydroxyl group at C-2; (3) a substrate controlled intramolecular Heck reaction to construct a quaternary carbon center (ring B); (4) introduction of a hypotaurine moiety at a late stage to furnish the E ring.
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