期刊
ORGANIC LETTERS
卷 20, 期 3, 页码 518-521出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03581
关键词
-
资金
- National Natural Science Foundation of China [21772086]
- Fundamental Research Funds for the Central Universities [020514380118]
- Nanjing University
Highly enantioselective synthesis of acyclic alpha-tertiary amines through asymmetric desymmetrization is reported. This approach is based on chiral phosphoric acid mediated, enantioselective, oxidative desymmetrization of 2-substituted 2-nitro-1,3-diolbenzylidine acetals in the presence of DMDO as an oxidant. The method allows for the formation of a wide variety of chiral 2-nitro-1,3-diols in high enantioselectivity, which could be transformed into optically pure, unnatural alpha-alkyl series. The synthetic utility of this method has been further demonstrated by the expedient construction of the core structure of natural products manzacidins enantioselectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据