Dual Photoredox/Nickel-Catalyzed Regioselective Cross-Coupling of 2-Arylaziridines and Potassium Benzyltrifluoroborates: Synthesis of β-Substitued Amines

A dual-visible light photoredox and nickel-catalyzed cross-coupling reaction of 2-arylaziridines and potassium benzyltri-fluoroborates is described for the first time. This strategy features high Junctional group tolerance, excltisive-regioselectivity for reaction at the more hindered C-N bond, easily accessible substrates, and mild redoxneutral reaction conditions. A variety of diversely substituted beta-substituted amines are obtained in generally good yields.