4.8 Article

Pd-Catalyzed Remote Meta-C-H Functionalization of Phenylacetic Acids Using a Pyridine Template

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ORGANIC LETTERS
卷 20, 期 2, 页码 425-428

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03336

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资金

  1. National Science Foundation [CHE-1465292]
  2. Scripps Research Institute
  3. China Scholarship Council [201406205013]
  4. Division Of Chemistry
  5. Direct For Mathematical & Physical Scien [1465292] Funding Source: National Science Foundation

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An effective pyridine based U-shaped template has been developed to enable a diverse range of meta-C-H functionalizations of phenylacetic acid scaffolds. This, new template has extended the reaction scope to cross-coupling with ArBF3K as well as iodination using 1,3-cliiodo-5,5-dinriethylhydantoin as the iodination reagent.

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