期刊
ORGANIC LETTERS
卷 20, 期 2, 页码 461-464出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03826
关键词
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资金
- National Natural Science Foundation of China [21472057, 21572074, 21772052, 21772053]
- Program of Introducing Talents of Discipline to Universities of China [B17019]
Efficient and enantioselective radical difluoroalkylation and perfluoroalkylation reactions of beta-ketoesters were successfully developed through an asymmetric photoredox and nickel catalysis cascade. This protocol provides R-f-containing quaternary stereocenters in up to 67% yield and 95:5 er with ethyl iododifluoroacetate and perfluoroalkyl iodides (C3F7I and C4F9I) as radical sources under extremely mild conditions.
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