期刊
ORGANIC LETTERS
卷 20, 期 3, 页码 499-501出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03719
关键词
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资金
- NIH NIGMS [R01GM111638]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM111638] Funding Source: NIH RePORTER
The first examples of (3 +, 2) annulations between azaoxyallyl cations and cyanamides and nitriles, to give, the corresponding 2-aminoimidazolones and imidazolones, are reported. On the basis of the isolation of unexpected imidate products with certain substrates, it is proposed that the reaction proceeds via fast kinetic O-alkylation followed by rearrangement to the thermodynamically favored 2-aminoimidazolones and imidazolones. The method was applied to the formal synthesis of the antihypertensive drug irbesartan.
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