期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 7, 页码 1113-1117出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob02987j
关键词
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资金
- Marie Curie ITN programme
- Engineering and Physical Sciences Research Council [EP/L017911/1, EP/R013799/1] Funding Source: researchfish
- EPSRC [EP/R013799/1, EP/L017911/1] Funding Source: UKRI
A method for the preparation of aryl alpha,alpha--difluoroethyl thioethers (ArSCF2CH3) is reported and the synthesis approach is extended to aryl alpha,alpha-difluoroethyl oxygen ethers. Selected building blocks are further elaborated in cross-coupling reactions and are incorporated into analogues of established trifluoromethyl ether drugs. Conformations are explored and log P studies of these motifs indicate that they are significantly more polar than their trifluoromethyl ether analogues rendering them attractive for bioactives discovery.
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