期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 18, 页码 3382-3388出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00327k
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A series of benzothiazolium-based hemicyanines (3a-3f) have been synthesized. Evaluation of their photophysical properties shows that they exhibit improved photophysical characteristics. In comparison with the available commercial MitoTrackers, the new probes revealed an enhanced Stokes shift (Delta lambda similar to 80 nm) and minimized aggregation for increased sensitivity. The synthesized probes are found to exhibit excellent selectivity for mitochondria! staining in an oligodendrocyte cell line. Probes show almost no fluorescence in aqueous environments, while the fluorescence is increased by similar to 10-fold in organic solvents, making it possible for mitochondria! imaging without the need for post-staining washing. Since the absorption peaks of probes are close to the laser wavelengths of 561 and 640 nm on a commercial confocal microscope, e.g. 3a exhibits lambda(abs )similar to 620 nm and lambda(em) similar to 702 nm, they could be useful probes for mitochondrial tracking in live cells.
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