4.6 Article

t-BuONa-mediated direct C-H halogenation of electron-deficient (hetero) arenes

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 6, 页码 886-890

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob03081a

关键词

-

资金

  1. NSFC [21172034, 21372039]

向作者/读者索取更多资源

An efficient halogenation of electron-deficient (hetero) arenes is described. The reaction utilizes common t-BuONa as a catalyst (for iodination) or a promoter (for bromination and chlorination), and perfluorobutyl iodide, CBr4 or CCl4 as the readily-available halogenating agents, respectively. The protocol features broad scope, high efficiency, mild conditions and gram scalability. An ionic pathway involving halogen bond formation and halophilic attack is proposed. The utility of the resulting iodinated heteroarenes is demonstrated in visible light-mediated C-aryl-C-aryl cross-coupling reaction.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据