期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 4, 页码 521-525出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob02680c
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资金
- Politecnico di Milano
- Universita degli Studi di Milano
A collection of systematically substituted 3-cyclo-butylcarbamoyl hydantoins was synthesized by a regioselective multicomponent domino process followed by easy coupling reactions. Calculations, NMR studies and X-ray analysis show that these scaffolds are able to project their side chains similar to common secondary structures, such as the alpha-helix and beta-turn, with favourable enthalpic and entropic profiles.
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