期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 20, 页码 3824-3830出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob03205f
关键词
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资金
- KAKENHI [JP26102732, JP26282211, JP17H02207, JP17H05800, JP16H01162, JP26882036, JP23241074, JP15H05836, JP16H01885]
- MEXT [S1411010]
- NEXT-program from JSPS [LR025]
- Mizutani Foundation for Glycoscience
- Mishima Kaiun Memorial Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [16H01162] Funding Source: KAKEN
As a mammalian toll-like receptor family member protein, TLR2 recognizes lipoproteins from bacteria and modulates the immune response by inducing the expression of various cytokines. We have developed fluorescence-labeled TLR2 ligands with either hydrophilic or hydrophobic fluorescence groups. The labeled ligands maintained the inflammatory IL-6 induction activity and enabled us to observe the internalization and colocalization of the TLR2 ligands using live-cell imaging. The time-lapse monitoring in the live-cell imaging of the fluorescence-labeled TLR2 ligand showed that TLR2/CD14 expression in the host cells enhanced the internalization of TLR2 ligand molecules.
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