期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 13, 页码 2264-2268出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00257f
关键词
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资金
- Natural Science Foundation of Anhui Province [1508085SMB208]
- Doctoral Startup Foundation of Wannan Medical College [wYRCQD201715]
- Educational Commission of Anhui Province of China [KJ2016A788]
- Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]
A two-photon active probe for physiological copper (Cu2+) detection is expected to play an important role in monitoring biological metabolism. Herein, a novel Schiff base derivative (E)-2,2-((4-((4-(diethylamino)-2-hydroxybenzylidene)amino)phenyl)azanediyl)bis(ethan-1-ol) (L) with remarkable two-photon activity was developed and synthetically investigated. L presents high selectivity and sensitivity for Cu2+ sensing in ethanol/HEPES buffer (v/v, 1:1), which is accompanied by the fluorescence switching off and subsequently on with the addition of EDTA. The mechanism for the detection of Cu2+ is further analyzed using H-1 NMR titration, mass spectra and theoretical calculations. Furthermore, since the probe L possesses good photophysical properties, excellent biocompatibility and low cytotoxicity, it is successfully applied to track Cu2+ in the cellular endoplasmic reticulum by two-photon fluorescence imaging, showing its potential value for practical applications in biological systems.
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