期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 16, 期 11, 页码 1971-1975出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob00173a
关键词
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资金
- National Science Foundation of China [21606238, 21476240, U1662133]
- Instrument Developing Project of the Chinese Academy of Sciences [YZ201521]
- CAS 100-Talent Program
A metal-free protocol of direct C(sp(3))-H cyanation with cyanobenziodoxolones functioning as both cyanating reagents and oxidants was developed. Unactivated substrates, such as alkanes, ethers and tertiary amines, were thereby transformed to the corresponding nitriles in moderate to high yields. Mechanistic studies indicated that the cyanation proceeded with two potential pathways, which is highly dependent on the substrates: (1) a free radical case for alkanes and ethers and (2) an oxidative case for tertiary amines.
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